How much higher is the pressure generated on the Cogent 2.o columns than 4um phases – FAQ Read More →
How similar fittings for chromatography can differ from different brands in HPLC – Tech Information Read More →
How tight should an autosampler vial cap be to prevent push through of the septa during injection – FAQ Read More →
How to choose a suitable mobile phase additive for negative ionization mode LCMS – Tips & Suggestions Read More →
How to eliminate retention time drift in LCMS with Aqueous Normal Phase ANP methods – Tips & Suggestions Read More →
How to get improved retention and peak shape for glutamine glutamic acid and aspartic acid – Tips & Suggestions Read More →
How to improve peak shapes, retention & carryover for polar compounds with the Cogent Diamond Hydride™ column – Tips & Suggestions Read More →
How to keep the Cogent Diamond Hydride column clean when using blood as a sample – Tips & Suggestions Read More →
I am not observing any peaks for succinic acid or alpha-ketoglutarate with the Cogent Diamond Hydride column – Tips & Suggestions Read More →
I see a strange saw tooth type of pattern in the UV baseline using my Cogent HPLC column what is it and how can I fix it – FAQ Read More →
I see extra peaks in my chromatography when I am not using the same filter – Tips & Suggestions Read More →
If an analyte is only soluble at basic pH can you use a basic mobile phase for my method – FAQ Read More →
If I use a buffer at pH 9 at 30 to 35C with the Zero Flow capillaries what lifetime should I expect from them – FAQ Read More →
Increasing selectivity and resolution for a xylose and ribose method – Tips & Suggestions Read More →
Is TFA or formic acid better as an acidic mobile phase additive for Cogent TYPE-C columns – FAQ Read More →
Issues arising from changes in mobile phase with acids to one with ammonium salts. Tips & Suggestions Read More →
Lower retention is observed when functional group in a compound is ionized – Tips & Suggestions Read More →
Modify selectivity in an ANP method of HPLC using different mobile phase pH – Tips & Suggestions Read More →
My LCMS source was getting white film on it and at the same time the background noise was very low so is my Diamond Hydride column bleeding packing material – FAQ Read More →
No need to use a high pH mobile phases for compounds with a high pKa – Tips & Suggestions Read More →