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How do I determine concentration of an impurity when I know the relative response factor (RRF)?

Reference Number: AA-03089 Created: 08/28/2017 09:36 AM Last Updated: 08/28/2017 10:43 AM

The concentration can be calculated once you have values for the following two equations:

     Response Factor (RF) = Peak Area / Concentration

     Relative Response Factor (RRF) = RFimpurity / RFAPI

You can use RRF and RFAPI to solve for RFimpurity. Then you can use the measured peak area of the impurity to solve for its concentration.
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