The Cogent Column Filter is compatible with any stationary phase in any HPLC Column.
The Cogent brand of in line, column filters are stainless steel (SS) frits encased in PEEK holders that traps unwanted particles before they get trapped in the frits of HPLC columns. When back pressure begins to build up, these column filters can be easily removed and disposed of, keeping the column’s frits fresh and clean.
NOTE: A compatibility concern to keep in mind is that the internal flow path of the Cogent Column Filter is designed for 4.6mm ID Columns. By placing a 4.6mm ID In line Filter with 2.1mm ID Column there could be band broadening if your flow path change and their current system tubing with what the Method System Suitability requirements are compatible. Since most analysts do not typically change the entire system tubing to run 2.1mm columns and use standard ID tubing like 0.005” ID, in this case the Cogent Column Filter would likely would work well.
If one is using a separate HPLC instrument hyphenated with an MS the system tubing is usually .005” ID and may be okay whereas if using an LCMS unit that is designed for LCMS, the system tubing might have a smaller ID, where this In line filter may not be best suited.
One additional factor that might make this In line Filter non-compatible for some users would be if they are observing issues with nucleotides or other compounds that interact with Stainless Steel. If metal interaction compatibility is an issue, the in line Filter element is made with Stainless Steel and may cause analyte adsorption/loss and/or poor peak shape. When analyzing biological samples, one might consider the benefits of employing a Titanium in line filter. Titanium offers a higher corrosion resistance compared to SS and is also more biocompatible for protein analysis.