Flecainide Acetate USP assay with HPLC – AppNote – MicroSolv Technology Corporation

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ARTICLES, APPNOTES, FAQ (9292)
- AppNotes Library (1888)
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October 27, 2022
Tanya

AppNotes Alternate Generic Methods / AppNotes Library / AppNotes Listed by Column / AppNotes Pharmaceuticals / AppNotes Reversed Phase Methods / AppNotes RP C18

Alternate column used for a similar USP assay method of flecainide acetate

This similar USP flecainide acetate is easily performed, and the 10 injections overlay below demonstrates run to run consistency and great peak symmetry. The peak efficiency is very good and peak tailing guidelines are easily met with RSD values of less than 1.0%.

This demonstrates a good alternate column for your flecainide acetate USP method.

Peak:
Flecainide Acetate

Method Conditions:
Column: Cogent RP C18™, 5um, 100Å
Catalog No.: 68518-15P
Dimensions: 4.6mm x 150mm

Note 1: For the full method conditions and details, consult the official United States Pharmacopeia–National Formulary (USP–NF.)
Note 2: Flecainide acetate inhibits the action of sodium and potassium ion channels in the heart, which raises the threshold for depolarization and correcting arrhythmias.

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