Which membrane is best for aqueous buffers when using syringe filters – FAQ

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ARTICLES, APPNOTES, FAQ (9292)
- AppNotes Library (1888)
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April 14, 2020
Bill Ciccone

ARTICLES, APPNOTES, FAQ / Filtration FAQ / Frequently Asked Questions?? / HPLC Tips and Suggestions / Syringe Filters and Filtration Information / Syringe Filters FAQ / Trouble Shooting Suggestions

The best membrane is a difficult question to answer as it depends on your sample that you are filtering and the solvent is it dissolved in.

For most HPLC and dissolution testing, hydrophilic Nylon or the PES membranes are generally used because they are durable, compatible with most aqueous solvents including water and have the lowest extractables with aqueous solvents. The best way to determine if Nylon or PES is compatible is to try them with your sample. You should analyze your sample (if possible) with and without filtering. There should be no change in your analysis.

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