What is the compatibility of Cogent TYPE-C Silica HPLC columns with UHPLC instruments – FAQ

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ARTICLES, APPNOTES, FAQ (9292)
- AppNotes Library (1888)
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April 14, 2020
Bill Ciccone

2.o™ HPLC Columns FAQ / Amide FAQ / ARTICLES, APPNOTES, FAQ / Bidentate C18 FAQ / Bidentate C8 FAQ / Cogent Amide Information / Cogent Bidentate C18 Information / Cogent Bidentate C8 Information / Cogent Diamond Hydride Information / Cogent DIOL Information / Cogent Phenyl Hydride Information / Cogent Silica-C Information / Cogent UDA Information / Cogent UDC-Cholesterol Information / Diamond Hydride FAQ / Diol FAQ / Frequently Asked Questions?? / HPLC Column Information / HPLC Columns FAQ / HPLC Suggestions and Information / HPLC Tips and Suggestions / Phenyl Hydride FAQ / Silica-C FAQ / TYPE-C Column Information / TYPE-C in General FAQ / UDC-Cholesterol FAQ

Cogent™ HPLC columns are compatible with ultra high performance liquid chromatography (UHPLC) instrumentation.

However, it is important to note the low pressure produced in Aqueous Normal Phase ANP and the pressure limits of these columns. The Cogent 2.o™ is considered “Near UHPLC” with pressure limits near 9,000 psi. If you are using ANP HPLC methods it is unlikely you will develop high pressure even at fast run rates due to the very low viscosity of the mobile phase used in these types of methods.

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