Working with ammonium acetate and LCMS requires attention to cleaning – Tips & Suggestions

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ARTICLES, APPNOTES, FAQ (9292)
- AppNotes Library (1888)
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April 14, 2020
Bill Ciccone

ARTICLES, APPNOTES, FAQ / Cogent Diamond Hydride Information / Diamond Hydride FAQ / HPLC Column Information / HPLC Tips and Suggestions / TYPE-C Column Information

Ammonium acetate is a wonderful additive for LCMS using HILIC or Aqueous Normal Phase (ANP) methods. However, be aware that even in low concentrations, the inlet source of the MS will become clogged with over time and will require cleaning.

If you notice that your peaks are disappearing or the integration of your desired peaks decrease, it is time to perform some preventative maintenance.

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