Retention of the Sulfonate Drug Topiramate
The structure of Topiramate leads us to think due to the Amino group and negative Log P value of -0.8, it will not be retained in Reversed Phase HPLC. However, in this Method, the compound is well retained.
Column: Cogent Bidentate C18™, 4µm, 100Å
Catalog No.: 40018 -05P-2
Dimensions: 2.1 x 50mm
—A: DI Water / 0.1% Formic Acid
—B: Acetonitrile / 0.1% Formic Acid
Injection vol.: 1µL
Flow rate: 0.3mL / minute
Detection: ESI – pos – Agilent 6210 MSD TOF Mass Spectrometer
Sample Preparation: Topiramate 0.01mg / mL in 50% A / 50% B solvent mixture.
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