Retention of the Sulfonate Drug Topiramate

The structure of Topiramate leads us to think due to the Amino group and negative Log P value of -0.8, it will not be retained in Reversed Phase HPLC. However, in this Method, the compound is well retained.



Peak:
Topiramate 340.1062 m/z (M + H)+

Method Conditions:
Column: Cogent Bidentate C18™, 4µm, 100Å
Catalog No.: 40018 -05P-2
Dimensions: 2.1 x 50mm
Mobile Phase:
A: DI Water / 0.1% Formic Acid
B: Acetonitrile / 0.1% Formic Acid
Gradient:

Time (minutes) %B
0 10
1 10
4 90
5 90
6 10
7 10

Injection vol.: 1µL
Flow rate: 0.3mL / minute
Detection: ESI – pos – Agilent 6210 MSD TOF Mass Spectrometer
Sample Preparation: Topiramate 0.01mg / mL in 50% A / 50% B solvent mixture.

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