It is well known that silanol groups present on the surface of Type I glass autosampler vials contribute to quantitative loss in the case of basic analytes. This is believed to occur primarily by electrostatic interaction and possibly by hydrogen bonding to some degree.

In order to investigate the nature of this interaction in more detail, we conducted a series of experiments using different sample diluents and used RSA™ Reduced Surface Activity autosampler vials.

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Effect of diluent on adsorption pdf    Download File