If the guard column is packed well with the same stationary phase as the analytical column and the guard system hardware has very little or no inherent dead volume, it should not affect the results you get compared to the Cogent guard system.

It is important to note that any guard column or extra tubing or fittings has the potential to degrade efficiency. You always want to minimize your tubing lengths and make sure you have good quality fittings and that you remove all kinks and bends in your tubing.

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