Several Tertiary Amines on a Molecule that is Easily Retained
This Method for the Analysis of Dipyridamole USP Tablet Formulation is easy to do. Note the excellent Resolution from capsule excipients, along with the excellent Peak shape for this complex, difficult molecule.
2. Tablet Excipients
Column: Cogent Bidentate C18™, 4μm, 100Å
Catalog No.: 40018-75P
Dimensions: 4.6 x 75mm
—A: DI Water / 0.1% Phosphoric Acid
—B: 80% Acetonitrile / 20% DI Water / 0.1% Phosphoric Acid
Injection vol.: 10μL
Flow rate: 1.5mL / minute
Detection: UV @ 280nm
Notes: Dipyridamole is a drug that inhibits thrombus formation when given chronically and causes vasodilation when given at high doses over short time. Modified release Dipyridamole is used in conjunction with aspirin (under the trade names Aggrenox in the USA or Asasantin Retard in the UK) in the secondary prevention of stroke and transient Ischaemic attack. Dipyridamole absorption is pH-dependent and concomitant treatment with gastric acid suppressors (such as a proton pump inhibitor) will inhibit uptake significantly.
Notes: We recommend dedicating TYPE-C™ Columns to Methods once they have been used with Phosphates.
No 82 Dipyridamole Analyzed with HPLC pdf 0.1 Mb Download File