Yes, if you are wiling to introduce Methanol into your Method.

For a 25mm syringe filter device; if you use 15-20mls of Methanol as a blank Filtrate, the Membrane will give you less back pressure after that for Aqueous samples. This “conversion” is due to “wetting” the Membrane with Methanol allowing more Aqueous Solvents to pass through it with less Back Pressure. However, depending on your detection, you may see some Methanol in your results.

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