Yes, if you develop a method that is optimized with the Cogent Silica-C™ columns compared with an ordinary silica column, the retention times are generally much more reproducible.

The reason for better precision or reproducibility is most likely that when using ordinary silica columns the uptake of water on the stationary phase changes from run to run and the retention often changes. Since the Silica-C™ column does not take up water, this issue does not take place.

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