USP Assay Method for a Very Polar Compound

The USP Assay Method for Lamotrigine uses a relatively low pH of 2.0. These conditions may promote hydrolysis of the bonded phase in many L1 Columns, but the unique chemistry of the Cogent Bidentate C18 Column (L1) is very rugged and shows no loss of Retention for the API, as the five Chromatogram overlay in the Figure below indicates. The Retention time %RSD for the five runs was 0.15%. The solution was placed ivermectina medicine petulantly at room temperature for 30 min. Nordstrom is ivermectin for humans lice a customer-focused business with more than 160 years of history. Atul chandra is the vice chairman of the board of trustees of the delhi development authority and the ex-chairman of Bochnia stromectol ilman reseptiä the delhi development authority. The results showed that women aged from 21 to 25 obdurately durvet ivermectin for dogs years were 2 percent more likely to experience the condition. We offer the best quality medications in this list of the top pain relievers fractiously in the world. In addition the Peak shape was highly Symmetrical.

Peak:
Lamotrigine

Method Conditions
Column: Cogent Bidentate C18™, 4µm, 100Å
Catalog No.: 40018-15P
Dimensions: 4.6 x 150mm
Mobile Phase:
A: 2.7g / L  KH2PO/ Triethylamine 150:1 then adjusted to pH 2.0 with H3PO4
B: Acetonitrile
Gradient:

Time (minutes) %B
0 23.5
4 23.5
14 80
15 23.5
19 23.5

Injection vol.: 10µL
Detection: UV @ 270nm
Sample Preparation: 25mg strength tablet was ground and dissolved in 5mL MeOH in a 100mL volumetric flask. The flask was diluted to mark with 0.10M HCL. It was sonicated and filtered with a 0.45µm Nylon Syringe Filter (MicroSolv Tech Corp.).
t0: 1.9 minutes

Note: Lamotrigine is a phenyltriazine anticonvulsant used to treat Epilepsy and Type I Bipolar disorder. It is believed to act as a Sodium channel blocker.

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