Simple Gradient Method with MS Detection

This Method by LCMS detection eliminates derivatization which may be necessary with GCMS Methods.  Reversed Phased Methods may run into poor separation of the small and very polar Melamine, resorting to ion pairing reagents to improve separation.  The use of these ion pairing reagents counterintuitively results in ionization suppression of the MS source.


Peaks:
1. Cyanuric acid NEG (M-H)- 128.0102 m/z 
2. Melamine  POS (M+H)+ 127.0727 m/z 

Method Conditions
Column: Cogent Diamond Hydride™, 4μm, 100Å
Catalog No.: 70000-15P-2
Dimensions: 2.1 x 150mm
Mobile Phase:
A: DI Water + 0.1% Acetic Acid
B: Acetonitrile + 0.1% Acetic Acid
Gradient:

 Time (minutes)  %B
0 100
15 50

Post Time: 5 minutes
Flow rate: 0.4mL / minute
Detection:  Agilent 6210 MSD TOF Mass Spectrometer
t0: 0.8 minutes

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