Make PTFE syringe filters hydrophilic – How to – MicroSolv Technology Corporation

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ARTICLES, APPNOTES, FAQ (9289)
- AppNotes Library (1888)
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- Frequently Asked Questions?? (3402)
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April 14, 2020
Bill Ciccone

ARTICLES, APPNOTES, FAQ / Filtration FAQ / Frequently Asked Questions?? / How To... Information / HPLC Tips and Suggestions / Syringe Filters and Filtration Information

Yes, if you are wiling to introduce methanol into your method.

For a 25mm device, if you use 15-20mls of methanol as a blank filtrate, the membrane will give you less back pressure after that for aqueous samples. This is due to “wetting” the membrane with methanol allowing more aqueous solvents to pass through it with less back pressure.

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