DATE: 14-APRIL-2020 Last Updated: 14-JUNE-2025
Yes, Cogent TYPE-C™ HPLC columns are fully compatible with Supercritical Fluid Chromatography (SFC) in terms of both hardware durability and stationary phase stability.
⚙️ Hardware & Material Compatibility
- Column hardware (stainless steel tubing, frits, and end fittings) is resistant to the pressures and chemical environment typical of SFC systems.
- The TYPE-C™ silica-based stationary phase is chemically bonded and thermally stable, making it suitable for exposure to supercritical CO₂ and common SFC co-solvents (e.g., methanol, ethanol, isopropanol).
- No degradation or swelling of the packing material is expected under standard SFC operating conditions.
🧪 Application Suitability
While the columns are physically and chemically compatible with SFC, we currently do not maintain SFC instrumentation in-house and therefore cannot provide validated SFC application data or method development support.
However, based on the unique surface chemistry of TYPE-C™ silica (featuring a covalently bonded silicon-hydride surface), these columns may offer distinct selectivity advantages in SFC, particularly for:
- Polar and moderately polar compounds
- Compounds that exhibit poor retention or peak shape in traditional silica or C18 SFC columns
- Applications requiring orthogonal selectivity to standard reversed-phase or bare silica SFC phases
📌 Summary
| Feature | Cogent TYPE-C™ Columns in SFC |
|---|---|
| Hardware compatibility | ✅ Yes |
| Stationary phase stability | ✅ Yes |
| Application support | ⚠️ Limited (no in-house SFC) |
| Selectivity potential | ✅ Unique, especially for polar analytes |
We welcome inquiries and are happy to provide technical guidance on column selection and method considerations, but we currently do not offer validated SFC methods or performance guarantees in this mode.
🔗 Contact Us for more information or to discuss your specific application.
