Category: Trouble Shooting Suggestions
/
/
/
Analyte retention decreases with mobile phase water content using the Cogent Bidentate C18 HPLC column has anything happened to the column - FAQ
Read More
Read More
Analyze phosphorylated compounds with the Cogent Diamond Hydride column - Tips & Suggestions
Read More
Read More
Analyzing metformin in plasma samples how do I obtain reproducible results and peak shapes - FAQ
Read More
Read More
Assuring retention of polar compounds in an Aqueous Normal Phase ANP gradient in positive ion mode LCMS - Tips & Suggestions
Read More
Read More
Autosampler Vials Sold by MICROSOLV will Fit Properly in Your Instruments - Tech Information
Read More
Read More
Biological extracts Diamond Hydride columns and LCMS ion source diminished peak height problem - FAQ
Read More
Read More
Broad Peaks That are Non Symmetrical in LCMS in Reversed Phase Solutions - Troubleshooting
Read More
Read More
Causes of high baseline noise with Cogent Diamond Hydride HPLC column - Tips & Suggestions
Read More
Read More
Changing retention times of amino acids in biological extracts using ammonium acetate in HPLC methods. - Troubleshooting.
Read More
Read More
Citric acid retention and peak shape has changed compared to data from a previous run what happened - FAQ
Read More
Read More
Difficulties with wavelength accuracy readings while performing a PQ of an HPLC - Tips & Suggestions
Read More
Read More
Do different retention times for peaks in the Resolution Test Mixture on different systems impact the integrity of my data - FAQ
Read More
Read More
Effects of Washing and Re-using Autosampler Vials on Sample Loss and Contamination - Tech Information
Read More
Read More
Eliminate broad split peaks in Aqueous Normal Phase ANP methods and a methanol diluent- Tips & Suggestions
Read More
Read More
Eliminate Retention Time Drift in LCMS With Aqueous Normal Phase ANP Methods - Tips & Suggestions
Read More
Read More
Eliminating Shoulder Peaks in an HPLC Method Using Cogent RP C18 Columns - Tips & Suggestions
Read More
Read More
For Sugars Analyzed by LCMS Sodium Acetate is recommended for Sensitivity of Na Adducts - Tips & Suggestions
Read More
Read More
Formic Acid Improves Peak Shapes Retention and Carryover for Polar Compounds With the Cogent Diamond Hydride HPLC Column - Tips & Suggestions
Read More
Read More
Ghost peaks appearing in results using a gradient with TFA which can degrade with time - Tips & Suggestions
Read More
Read More
Glucose pyruvate taurocholic acid gamma glutamylcysteine and other analysis - Tips & Suggestions
Read More
Read More
High molecular weight compounds that won't retain on Cogent Diamond Hydride column try Cogent Bidentate C8 300 - Tips & Suggestions
Read More
Read More
High Pressure Develops after Flushing a Cogent Diamond Hydride HPLC Column with Acetonitrile Cause and Solution - FAQ
Read More
Read More
How Can I Restore my Diamond Hydride HPLC Column After I Ran Out of Mobile Phase and Air Was Accidently Introduced into it - Tips & Suggestions
Read More
Read More
How do I Avoid Distorted Peak Shapes When Using a Basic Mobile Phase pH for the Analysis of a Lipophilic Amine - Tips & Suggestions
Read More
Read More
How Tight Should an Autosampler Vial Cap be to Prevent Push Through of the Septa During Injection - HPLC Primer
Read More
Read More
How to keep the Cogent Diamond Hydride column clean when using blood as a sample - Tips & Suggestions
Read More
Read More
I see a strange saw tooth type of pattern in the UV baseline using my Cogent HPLC column what is it and how can I fix it - FAQ
Read More
Read More
Increasing Selectivity and Resolution for a Xylose and Ribose HPLC Method Resolution - Tips & Suggestions
Read More
Read More
Is TFA or formic acid better as an acidic mobile phase additive for Cogent TYPE-C columns - FAQ
Read More
Read More
Lower Retention is Observed When Functional Group in a Compound Should be Ionized - Troubleshooting Tips
Read More
Read More
My LCMS source was getting white film on it and at the same time the background noise was very low so is my Diamond Hydride column bleeding packing material - FAQ
Read More
Read More
No Peaks for Succinic Acid or Alpha-kKtoglutarate With the Cogent Diamond Hydride LCMS Column - Tips & Suggestions
Read More
Read More
Protecting HPLC Columns and When to Use Guard Columns vs Cogent Column Filters - Tips & Suggestions
Read More
Read More
Restoring the Initial Method Results Analyzing AMP ADP ATP UDP and GPT in Biological Extracts - Troubleshooting
Read More
Read More
Retention And or Peak Shape for Citric Acid has Changed Compared to Data from a Previous HPLC Run - Tips & Suggestions
Read More
Read More
Since Cogent TYPE-C Silica columns use a transition metal catalyst in production what is the presence of any trace quantity on the surface of the stationary phase- FAQ
Read More
Read More
Sodium Ion Interference in ANP Methods: Challenges in Analyzing Sodium Succinate - Tips & Suggestions
Read More
Read More
Suggestion for separation of phenylephrine HCl acetaminophen and dextromethorphan - Tips & Suggestions
Read More
Read More
The effect of ionic strength of the mobile phase additive for HPLC columns in Aqueous Normal Phase - Tips & Suggestions
Read More
Read More
Troubleshooting Problems With Poor HPLC Results Before Examining the Column - Tips & Suggestions
Read More
Read More
Using a Constant Pressure Method on two Instruments Producing Different Flow Rates- Tips & Suggestions
Read More
Read More
Using the wavelength calibration solution holmium oxide for HPLC UV detector performance qualification - Tips & Suggestions
Read More
Read More
What are some common sources of variance during sample preparation in an analytical application - FAQ
Read More
Read More
What can cause changing retention times and a peak showing up in my blank with a Silica-C column - FAQ
Read More
Read More
What effect does high injection volume have on column performance in Aqueous Normal Phase ANP HPLC- FAQ
Read More
Read More
What is the effect of extra column volume for different HPLC instruments on the same method - FAQ
Read More
Read More
What is the maximum concentration of ammonium fluoride to use in a mobile phase to avoid column damage - Tips & Suggestions
Read More
Read More
What problems can occur when using a dedicated Reversed Phase HPLC instrument for an Aqueous Normal Phase ANP method for the first time - FAQ
Read More
Read More
What will the pressure be with a mobile phase of 90% methanol and 10% DI water with a 4.6 x 250mm Cogent TYPE-C HPLC column - FAQ
Read More
Read More
When I run gradients on my HPLC and switch from one gradient to another my baseline shows as negative and if I auto zero it becomes positive for the remainder of the run but when I start again it is negative - Primer
Read More
Read More
Why am I observing broad split peaks in Aqueous Normal Phase ANP when using acetonitrile and methanol diluents - FAQ
Read More
Read More
Why are Pipettors not Recommended for Dispensing Non Aqueous Liquids Accurately and Precisely - FAQ
Read More
Read More
Why do I have lower than normal back pressure with Cogent Diamond Hydride HPLC columns - FAQ
Read More
Read More
Why do I see large intermittent pressure spikes in HPLC runs and can it be a defective column - FAQ
Read More
Read More