Category: Mobile Phase Preparation and Solvent Handling
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Learn about pressure limits, handling, and safe use of mobile‑phase bottles and sparging components. This section provides practical guidance to prevent damage, ensure safe operation, and support reliable solvent delivery.
10mM Ammonium Acetate Buffer 90:10 in Acetonitrile Preparation for HPLC and LCMS - Tips & Suggestions
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Ammonium Fluoride Affect On Chromatography Using Cogent TYPE-C HPLC Columns - Tech Information
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Avoid Spurious Peaks from Nylon Syringe Filters with DI Water Using Electrochemical Detection - Tips & Suggestions
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Back Pressure That is Lower than Normal Using a Cogent Diamond Hydride HPLC Column - Tech Information
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Buffer Concentration can Affect ANP Retention of Acids in HPLC Analyses - Tips and Suggestions
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Choose a Suitable Mobile Phase Additive for Negative Ionization Mode in LCMS - Tips & Suggestions
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Cocaine and Polar Metabolites ( Ecgonine) Separation using LC‑MS / MS - Tips and Suggestions
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For Sugars Analyzed by LCMS Sodium Acetate is recommended for Sensitivity of Na Adducts - Tips & Suggestions
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If an analyte is only soluble at basic pH can you use a basic mobile phase for my method - FAQ
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Is TFA or formic acid better as an acidic mobile phase additive for Cogent TYPE-C columns - FAQ
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LCMS Challenges with HILIC Mobile Phases from Salt Buildup and Ion Suppression Explained - Tips & Suggestions
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My retention times are changing after storing my buffer and what could be causing this and tips to help avoid issues - FAQ
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Phosphoric Acid and Sodium Phosphate Use with Cogent Diamond Hydride Columns - Tech Information
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Positive or Negative ion mode Salt Suggestions for LC-MS Method Development - Tips & Sugeestions
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Prepare a 16mM Ammonium Acetate Buffer 90:10 in Acetonitrile for HPLC - Tips & Suggestions
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Restoring the Initial Method Results Analyzing AMP ADP ATP UDP and GPT in Biological Extracts - Troubleshooting
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Simple Sugars Methods using Triethylamine TEA in Aqueous Normal Phase ANP Methods - Tips & Suggestions
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To obtain greater sensitivity than Na adducts for sugars could you add ammonia NH4 instead - FAQ
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Type of gradient to use for analysis of hydrophilic and hydrophobic molecules in the same HPLC or LCMS run - Tips & Suggestions
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Using methanol instead of acetonitrile in an HPLC method should be done with caution - Tips & Suggestions
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What is the durability of the SOLVFIL when used with standard mobile phases and buffered mobile phases - FAQ
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What is the maximum salt concentration to use with Cogent TYPE-C HPLC columns with HPLC or LCMS - FAQ
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