Cogent HPS™ Cyano L10 in RP with Improved PEAK Shape

High‑Purity Cyano HPLC Columns for Improved Peak Shape and USP® L10 Methods in Reversed Phase

Cogent HPS™ Cyano HPLC columns are engineered for high efficiency, excellent peak shape, and reliable performance in USP® L10 and routine reversed‑phase methods. These base‑deactivated cyano columns are manufactured using MICROSOLV’s proprietary high‑purity silica, delivering consistent separations and improved resolution for demanding analytical workflows.

Designed for laboratories that require dependable, long‑term performance, Cogent HPS™ Cyano columns have been used successfully for in‑house and USP methods for more than 20 years.

Advanced Cyano Chemistry on High‑Purity Silica

Cogent HPS™ Cyano columns are non‑end capped and bonded with a cyano (CN) ligand on 120 Å, 5 µm high‑purity silica. The silica surface is base deactivated, which helps minimize secondary interactions and leads to improved peak symmetry, especially for basic or polar compounds.

This combination of controlled surface chemistry and high‑purity silica results in:

• Better peak shapes

• Higher resolution

• Consistent retention and selectivity

• Reliable performance in routine reversed‑phase methods

Designed for Reversed‑Phase HPLC

These cyano columns are packed and ready for reversed‑phase HPLC applications, offering an alternative selectivity to traditional alkyl phases while maintaining robustness for everyday use. The chemistry is well suited for analysts seeking improved separations without sacrificing method stability. The columns are supplied with Reversed Phase solvents as the storage solvent.

Available Formats and Configurations

Cogent HPS™ Cyano columns are available in a wide range of formats to support analytical development and scale‑up:

• Analytical columns

• Guard columns

• Preparative columns

• 5 µm particle size

• 120 Å porosity

This flexibility allows seamless method transfer from analytical to preparative scale.

Key Features and Benefits

• Designed for USP® L10 methods

• High‑purity, base‑deactivated silica

• Non‑end capped cyano (CN) bonded phase

• Improved peak shape and resolution

• Optimized for reversed‑phase HPLC

• Proven performance over decades of laboratory use

• Available in analytical, guard, and prep sizes

View more information about Cogent HPS™ columns.

Column Protection Recommendation

Important: MICROSOLV technical support strongly recommends the use of the Cogent column filter, which is included with each column, whenever possible. Column filters help protect against particulates, extend column life, and maintain consistent chromatographic performance.

👉 Learn more about the Cogent column filter for HPLC column protection