HPLC Column, HPS Cyano, 5um, 2.1mm ID x 50mm Length, 120A. Cogent Brand. 1 EA.
Additional Information:
Cogent HPS Cyano™ HPLC Columns are designed for versatile reversed-phase separations of polar and neutral compounds requiring moderate retention, rapid equilibration, and reproducible chromatographic performance. Manufactured using a monofunctional three-carbon ligand with a terminal cyano functional group bonded to high-purity 120Å silica and fully end capped, this stationary phase offers unique selectivity characteristics that are widely used as an alternative for USP L10 methods and for new method development. The HPS product line was developed to provide a high-value option for laboratories seeking performance characteristics comparable to established cyano phases from leading manufacturers.
75025-05P-2 is packed with 5 µm HPS Cyano™ particles in a 2.1 mm ID x 50 mm analytical format. The short 50 mm column length is optimized for rapid analysis, method development, and high-throughput workflows where reduced run times and lower solvent consumption are important. The narrow-bore format is particularly beneficial for LC-MS applications, providing efficient use of mobile phase while supporting enhanced sensitivity when paired with appropriately configured instrumentation.
The HPS Cyano™ stationary phase is commonly used for polar and neutral compounds analyzed using reversed-phase chromatography. Compared to non-modified silica columns, the cyano phase provides faster equilibration between runs and shorter retention times while maintaining excellent selectivity. This column is frequently selected for LC-MS methods, analytical screening, and method development applications where speed, reproducibility, and unique cyano selectivity are valued.
Key Benefits
HPS Cyano™ stationary phase
USP L10 equivalent chemistry
Fully end capped
Monofunctional cyano bonded phase
High-purity 120Å silica
5 µm particle size
Lower operating backpressure
Faster equilibration between runs
Shorter retention than non-modified silica
Excellent for LC-MS applications
Typical Applications
USP L10 methods
LC-MS and LC-MS/MS methods
Reversed-phase HPLC
Polar compound analysis
Neutral compound analysis
Method development
Method screening
Pharmaceutical analysis
Routine quality control
Preparative method scouting
Specifications
Product Type: Analytical HPLC Column
Stationary Phase: HPS Cyano™
USP Classification: L10
Chromatography Mode: Reversed Phase
Particle Size: 5 µm
Pore Size: 120Å
Column Dimensions: 2.1 mm ID x 50 mm
Recommended Flow Rate: 0.2–0.3 mL/min
Column Hardware: Stainless Steel
Brand: Cogent
Important Notes
Suitable for reversed-phase chromatography
USP L10 equivalent chemistry
Fully end capped stationary phase
Designed for polar and neutral compounds
Provides faster equilibration than non-modified silica columns
Delivers shorter retention times than silica phases
Ideal for LC-MS applications
2.1 mm ID columns require an HPLC system capable of delivering reliable low flow rates
Low-volume detector flow cells are recommended for optimal performance
Frequently compared with established cyano columns from Inertsil™ and Luna™ product families
50 mm length minimizes solvent usage and analysis time