Working with ammonium acetate and LCMS requires attention to cleaning - Tips & Suggestions
April 14, 2020
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Ammonium acetate is a wonderful additive for LCMS using HILIC or Aqueous Normal Phase (ANP) methods. However, be aware that even in low concentrations, the inlet source of the MS will become clogged with over time and will require cleaning.

If you notice that your peaks are disappearing or the integration of your desired peaks decrease, it is time to perform some preventative maintenance.

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