Causes of high baseline noise with Cogent Diamond Hydride HPLC column – Tips & Suggestions

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ARTICLES, APPNOTES, FAQ (9289)
- AppNotes Library (1888)
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- Frequently Asked Questions?? (3402)
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December 19, 2017
Bill Ciccone

ARTICLES, APPNOTES, FAQ / Cogent Diamond Hydride Information / Diamond Hydride FAQ / HPLC Column Information / HPLC Tips and Suggestions / TYPE-C Column Information

What would cause high background noise using a Cogent Diamond Hydride™ HPLC column?

One possible reason background noise would be high could be if something from the sample that was injected and was stuck on the column frits or on the stationary phase and it is slowly bleeding off. Another cause could be if harsh pH conditions were used.

Either of these can occur sometimes without the user knowing it especially if the instrument and column are shared and they are not flushed properly between uses.

Click HERE for Cogent Diamond Hydride HPLC Column Ordering Information

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