Why would I want to use an HPLC column that is not end capped – FAQ

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ARTICLES, APPNOTES, FAQ (9289)
- AppNotes Library (1888)
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- Frequently Asked Questions?? (3402)
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April 14, 2020
Bill Ciccone

HPLC Column Information / HPLC Suggestions and Information / HPLC Tips and Suggestions / TYPE-C Column Information

End-capping the stationary phase is a great idea for neutral and non-polar compounds that are hydrophobic. This is common with traditional Reversed Phase stationary phases.

Polar compounds do not retain well enough on these end-capped columns but might retain and separate on non end-capped columns due to the increased polar nature of the stationary phase. However, there are better options.

While the Cogent TYPE-C™ columns do not require to be end-capped, they can retain both polar and non polar compounds in Reversed Phase or Aqueous Normal Phase ANP.

Click here to learn about TYPE-C HPLC columns

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