Catalog Number - 70000-15P

The 70000‑15P Diamond Hydride HPLC Column is one of the most established and widely adopted columns in the Diamond Hydride HILIC family. It is recognized for delivering reliable retention, excellent selectivity, and long column lifetime for the analysis of highly polar compounds using conventional HPLC instrumentation.

Why This Column Is a Laboratory Standard

The 4.6 mm × 150 mm format represents the classic analytical HPLC configuration, offering an ideal balance of:

• High resolving power for complex polar mixtures

• Robust peak shapes with excellent reproducibility

• Compatibility with standard HPLC systems and UV detectors

• Flexible method development and scaling

For many laboratories, this column serves as the reference platform for HILIC separations, method development, and validation work.

Diamond Hydride™ Stationary Phase Advantage

Manufactured using Cogent TYPE‑C™ silica hydride technology, the Diamond Hydride stationary phase provides fundamental advantages over conventional bonded‑silica HILIC phases:

• Faster equilibration, reducing downtime between injections

• Stable, reproducible retention mechanisms, even with high organic content

• Extended column lifetime, supporting long‑term routine use

The silica hydride surface supports mixed‑mode interactions that are particularly effective for challenging analytes.

This column is routinely used for:

• Small, highly polar molecules

• Amino acids and organic acids

• Polar and non‑polar peptides

• Metabolites and other biologically relevant compounds

High‑Resolution HPLC and UV Detection

The 150 mm column length delivers increased plate count and improved separation of closely eluting compounds, making this column especially effective for:

• Fast analysis of very polar compounds using UV detection

• Applications where shorter columns do not provide sufficient resolution

• Routine and regulated methods where robustness and repeatability are critical

Because of its standard internal diameter, the column comfortably supports higher injection volumes and traditional detector configurations without requiring specialized low‑dead‑volume systems.

LC‑MS Compatibility

While optimized for conventional HPLC workflows, the 70000‑15P is also mass‑spectrometry compatible and frequently used in LC‑MS environments where standard flow operation is acceptable or where post‑column flow splitting is employed.

System Requirements

• Typical operating flow rates: ~0.8–1.5 mL/min, depending on method and mobile‑phase viscosity

• Compatible with all conventional analytical HPLC systems

• No special low‑flow capability required

Flow rates may be optimized further based on resolution targets, pressure limits, and detector configuration.