Catalog Number - 82061-P50-250

Cogent NP Silica™ Process HPLC Columns are trusted by leading laboratories, pilot plants, and production facilities worldwide for large-scale purification, process chromatography, and manufacturing applications. Manufactured from ultra-high purity, low metal content, 100Å silica that remains completely unmodified, this stationary phase provides the native silica selectivity required for the purification of lipids, hydrophilic compounds, polar analytes, and other challenging sample types. Suitable for both HILIC and Normal Phase chromatography, this stationary phase is equivalent to USP L3 silica chemistry and has been successfully used for many years in pharmaceutical, chemical, food additive, nutraceutical, cannabis, and forensic applications.

82061-P50-250 is packed with 10 µm NP Silica™ particles in a 50 mm ID x 250 mm process column format. The larger particle size enables operation at high flow rates while producing substantially lower backpressure than smaller particle columns. The 50 mm internal diameter provides exceptional sample loading capacity, while the 250 mm length maximizes retention, peak capacity, and chromatographic resolution for demanding process-scale purification and production chromatography applications.

The 10 µm particle design has made this column a proven choice for preparative HPLC, process development, and production-scale chromatography worldwide. For many years, Cogent NP Silica™ columns have been used in the purification and manufacture of pharmaceuticals, specialty chemicals, food additives, nutraceuticals, natural products, and other high-value compounds. Because the stationary phase chemistry remains consistent across analytical, preparative, and process-scale formats, methods developed on smaller columns can often be scaled directly to 50 mm ID columns with predictable chromatographic behavior, helping streamline process transfer, pilot plant operations, and commercial manufacturing.

Key Benefits

• NP Silica™ stationary phase

• USP L3 equivalent chemistry

• Ultra-high purity silica

• Low metal content silica

• Unmodified silica surface

• 100Å pore size

• 10 µm particle size

• Lower operating backpressure

• Exceptional sample loading capacity

• Proven for process chromatography and production purification

Typical Applications

• Process HPLC

• Production chromatography

• Compound purification

• Lipid purification

• Polar compound separations

• Hydrophilic compound purification

• HILIC chromatography

• Normal Phase chromatography

• Pharmaceutical manufacturing

• Chemical and food additive purification

Specifications

• Product Type: Process HPLC Column

• Stationary Phase: NP Silica™

• USP Classification: L3

• Chromatography Modes: HILIC and Normal Phase

• Particle Size: 10 µm

• Pore Size: 100Å

• Column Dimensions: 50 mm ID x 250 mm

• Recommended Flow Rate: 80–200 mL/min

• Sample Loading Capacity: Process Scale

• Column Hardware: Stainless Steel

• Brand: Cogent

Important Notes

• Suitable for HILIC and Normal Phase chromatography

• USP L3 equivalent stationary phase

• Unmodified silica surface chemistry

• Manufactured from ultra-high purity, low metal content silica

• Designed for purification of hydrophilic, polar, and charged compounds

• Lower operating pressure than smaller particle process columns

• Exceptional loading capacity for production-scale purification

• Frequently used in pharmaceutical, chemical, food additive, nutraceutical, cannabis, and forensic applications

• Proven process chromatography technology trusted worldwide for many years

• Directly scalable from analytical and preparative NP Silica™ column methods

• Excellent for process development, manufacturing support, and commercial purification

• Requires a process HPLC system capable of supporting flow rates of approximately 80–200 mL/min and large-diameter columns

• 250 mm length provides maximum retention, peak capacity, and chromatographic resolution for demanding purification applications

Special Order Item Information

• Please review the Special Order Item Information for complete details.

• For pricing confirmation, availability, lead times, or application assistance, please contact MICROSOLV Customer Service.