Catalog Number - 82061-P21-PG1

Cogent NP Silica™ Preparative Guard Column Cartridges are designed to protect valuable preparative HPLC columns from particulate matter, strongly retained contaminants, and sample matrix components that can shorten column life and reduce chromatographic performance. Packed with ultra-high purity, low metal content, 100Å NP Silica™ that remains completely unmodified, these guard cartridges provide the same chromatographic selectivity as the analytical or preparative column they are protecting, helping maintain method consistency and reproducibility.

82061-P21-PG1 is packed with 10 µm NP Silica™ particles in a 21.2 mm ID x 10 mm preparative guard cartridge format. The cartridge is housed in stainless steel hardware with stainless steel frits and is intended for use ahead of a compatible NP Silica™ preparative column. By capturing contaminants before they reach the primary column bed, the guard cartridge helps extend column lifetime, reduce downtime, and lower operating costs in demanding preparative HPLC environments.

For many years, Cogent NP Silica™ preparative columns and guard cartridges have been used in pharmaceutical, cannabis, chemical, and forensic laboratories worldwide. This guard cartridge is particularly valuable in purification workflows involving complex samples where protecting the preparative column is critical to maintaining performance, loading capacity, and purification efficiency.

Key Benefits

• NP Silica™ stationary phase

• USP L3 equivalent chemistry

• Ultra-high purity silica

• Low metal content silica

• Unmodified silica surface

• 100Å pore size

• 10 µm particle size

• Protects preparative columns from contamination

• Helps extend preparative column life

• Maintains chromatographic performance

Typical Applications

• Preparative HPLC

• Column protection

• Compound purification

• Lipid purification

• Polar compound separations

• Hydrophilic compound purification

• HILIC chromatography

• Normal Phase chromatography

• Pharmaceutical purification

• Cannabis purification

Specifications

• Product Type: Preparative Guard Column Cartridge

• Stationary Phase: NP Silica™

• USP Classification: L3

• Chromatography Modes: HILIC and Normal Phase

• Particle Size: 10 µm

• Pore Size: 100Å

• Cartridge Dimensions: 21.2 mm ID x 10 mm

• Hardware Material: Stainless Steel

• Frit Material: Stainless Steel

• Brand: Cogent

Important Notes

• Suitable for HILIC and Normal Phase chromatography

• USP L3 equivalent stationary phase

• Unmodified silica surface chemistry

• Manufactured from ultra-high purity, low metal content silica

• Designed to protect preparative NP Silica™ columns from particulates and strongly retained contaminants

• Helps extend preparative column service life

• Maintains chromatographic performance and reproducibility

• Recommended for demanding purification and preparative workflows

• Frequently used in pharmaceutical, cannabis, chemical, and forensic laboratories

• This preparative guard column cartridge requires the Cogent 21.2 mm ID Preparative Guard Column Holder (Catalog Number 83000-P21-GH) for installation and operation.

• Compatible with Cogent 21.2 mm ID NP Silica™ preparative columns

• A specialized preparative HPLC system is required for columns of this size

Special Order Item Information

• Please review the Special Order Item Information for complete details.

• For pricing confirmation, availability, lead times, or application assistance, please contact MICROSOLV Customer Service.