Catalog Number - 82061-P21-100

Cogent NP Silica™ Preparative HPLC Columns are trusted by leading laboratories worldwide for compound purification, method scale-up, and process chromatography applications. Manufactured from ultra-high purity, low metal content, 100Å silica that remains completely unmodified, this stationary phase provides the native silica selectivity required for the purification of lipids, hydrophilic compounds, polar analytes, and other challenging sample types. The stationary phase is suitable for both HILIC and Normal Phase chromatography and is equivalent to USP L3 silica chemistry.

82061-P21-100 is packed with 10 µm NP Silica™ particles in a 21.2 mm ID x 100 mm preparative column format. The larger particle size allows operation at higher flow rates while producing lower backpressure than smaller particle columns. The 21.2 mm internal diameter provides significantly greater sample loading capacity than analytical columns, making it ideal for preparative separations, compound isolation, fraction collection, and purification workflows.

For many years, 10 µm NP Silica™ columns have been used in pharmaceutical, cannabis, chemical, and forensic laboratories around the world for preparative HPLC and purification applications. The stationary phase chemistry is directly scalable from analytical NP Silica™ columns, allowing methods developed on smaller columns to be transferred predictably to preparative formats. This column is well suited for purification of hydrophilic and charged compounds where high loading capacity, recovery, and reproducible performance are critical.

Key Benefits

• NP Silica™ stationary phase

• USP L3 equivalent chemistry

• Ultra-high purity silica

• Low metal content silica

• Unmodified silica surface

• 100Å pore size

• 10 µm particle size

• Lower operating backpressure

• High sample loading capacity

• Ideal for preparative HPLC and purification

Typical Applications

• Preparative HPLC

• Compound purification

• Lipid purification

• Polar compound separations

• Hydrophilic compound purification

• HILIC chromatography

• Normal Phase chromatography

• Pharmaceutical purification

• Cannabis purification

• Forensic laboratory applications

Specifications

• Product Type: Preparative HPLC Column

• Stationary Phase: NP Silica™

• USP Classification: L3

• Chromatography Modes: HILIC and Normal Phase

• Particle Size: 10 µm

• Pore Size: 100Å

• Column Dimensions: 21.2 mm ID x 100 mm

• Recommended Flow Rate: 15–40 mL/min

• Sample Loading Capacity: Preparative Scale

• Column Hardware: Stainless Steel

• Brand: Cogent

Important Notes

• Suitable for HILIC and Normal Phase chromatography

• USP L3 equivalent stationary phase

• Unmodified silica surface chemistry

• Manufactured from ultra-high purity, low metal content silica

• Designed for purification of hydrophilic, polar, and charged compounds

• Lower operating pressure than smaller particle preparative columns

• High loading capacity for compound isolation and purification

• Frequently used in pharmaceutical, cannabis, chemical, and forensic laboratories

• Proven preparative HPLC technology used globally for many years

• Directly scalable from analytical NP Silica™ column methods

• Excellent for method scale-up and process development

• Requires a preparative HPLC system capable of supporting higher flow rates and larger column dimensions

• 100 mm length provides an effective balance of throughput and purification performance

Special Order Item Information

• Please review the Special Order Item Information for complete details.

• For pricing confirmation, availability, lead times, or application assistance, please contact MICROSOLV Customer Service.