Catalog Number - 68534-05P-4

Cogent RP Cyano™ HPLC Columns are designed for reversed-phase separations of polar and neutral compounds where alternative selectivity to traditional alkyl-bonded phases is desired. Manufactured using ultra-high purity silica bonded with a three-carbon ligand and terminal Cyano functionality, this stationary phase provides unique chromatographic characteristics that make it an excellent choice for USP L10 methods. RP Cyano™ is often selected when shorter retention, rapid equilibration, and different selectivity than C18 columns are required.

68534-05P-4 is packed with 5 µm RP Cyano™ particles in a 4.0 mm ID x 50 mm format with a 100Å pore size. The 5 µm particle size provides lower operating backpressure than smaller particles while maintaining excellent efficiency and reproducibility. The short 50 mm column length is ideal for rapid analyses, high-throughput workflows, and method development applications where reduced run times are important.

The RP Cyano™ stationary phase is not end capped and is frequently used for analysis of polar and neutral compounds in reversed-phase HPLC. Compared to non-modified silica columns, it provides shorter retention times and faster equilibration between runs. Packed and shipped in reversed-phase solvents. See Cogent NP Cyano Columns Packed in Normal-Phase Solvents for applications requiring normal-phase chromatography.

Key Benefits

• RP Cyano™ stationary phase

• USP L10 equivalent chemistry

• Ultra-high purity silica support

• Three-carbon linker with terminal Cyano group

• Not end capped

• 100Å pore size

• Suitable for reversed-phase chromatography

• Alternative selectivity to C18 and C8 columns

• Faster equilibration between runs

• Ideal for rapid analytical methods

Typical Applications

• Reversed-phase HPLC

• USP L10 methods

• Polar compound separations

• Neutral compound separations

• Method development

• Routine quality control testing

• Pharmaceutical analysis

• Chemical analysis

• High-throughput laboratories

• Alternative selectivity screening

Specifications

• Product Type: HPLC Column

• Stationary Phase: RP Cyano™

• Chromatography Mode: Reversed Phase

• USP Classification: L10

• Particle Size: 5 µm

• Pore Size: 100Å

• Column Dimensions: 4.0 mm ID x 50 mm

• Recommended Flow Rate: 0.8–1.5 mL/min

• Column Hardware: Stainless Steel

• Brand: Cogent

Special Order Item Information

• Please review the Special Order Item Information for complete details.

• For pricing confirmation, availability, lead times, or application assistance, please contact MICROSOLV Customer Service..

Important Notes

• Suitable for reversed-phase chromatography

• USP L10 equivalent chemistry

• Not end capped

• Provides alternative selectivity compared to C18 and C8 columns

• Often used for polar and neutral compounds

• Faster equilibration than non-modified silica columns

• Short 50 mm length helps reduce run times and solvent consumption

• Packed and shipped in reversed-phase solvents

• Cogent NP Cyano Columns Packed in Normal-Phase Solvents are also available

• This is a Special Order Item