Catalog Number - 68524-P50-50-3M

Cogent RP Phenyl™ Wide Pore Process HPLC Columns are designed for high-capacity purification, process development, and production-scale chromatography involving larger aromatic compounds and structurally related analytes. Manufactured using ultra-high purity silica bonded with a three-carbon linker and terminal Phenyl functionality, this stationary phase is fully double end-capped to minimize secondary interactions and provide highly reproducible chromatographic performance. The 300Å wide pore structure improves accessibility for larger molecules while maintaining the aromatic selectivity characteristic of RP Phenyl™ chemistry.

68524-P50-50-3M is packed with 5 µm RP Phenyl™ Wide Pore particles featuring a 300Å pore size in a 50 mm ID x 50 mm process-scale format. The 5 µm particle size performs well at elevated process flow rates while maintaining moderate operating backpressure. The large internal diameter provides substantial sample loading capacity, while the shorter column length helps reduce run times and solvent consumption, making this column ideal for rapid process development, production purification, and manufacturing-scale chromatographic applications.

The 50 mm ID x 50 mm format is particularly well suited for purification of larger positional isomers, tocopherols, flavonoids, polynuclear aromatic hydrocarbons, nitro-aromatic compounds, active pharmaceutical ingredients (APIs), natural products, peptides, and related compounds containing aromatic structures. Typical operating flow rates are approximately 80–140 mL/min depending on mobile phase composition, system pressure limitations, and application requirements. A process-scale HPLC system capable of supporting these flow rates and sample loads is required.

Key Benefits

• RP Phenyl™ Wide Pore stationary phase

• USP L11 equivalent chemistry

• Ultra-high purity silica support

• Fully double end-capped

• Phenyl bonded phase

• 300Å pore size

• Suitable for reversed-phase chromatography

• Enhanced aromatic selectivity

• Improved accessibility for larger molecules

• High sample loading capacity

• Ideal for rapid process-scale purification

Typical Applications

• Process HPLC

• Production-scale purification

• Large positional isomer separations

• Tocopherol purification

• Flavonoid purification

• Polynuclear aromatic hydrocarbon separations

• Nitro-aromatic compound purification

• Active pharmaceutical ingredient (API) purification

• Natural product isolation

• Peptide purification

• Process development and scale-up

Specifications

• Product Type: Process HPLC Column

• Stationary Phase: RP Phenyl™ Wide Pore

• Chromatography Mode: Reversed Phase

• USP Classification: L11

• Particle Size: 5 µm

• Pore Size: 300Å

• Column Dimensions: 50 mm ID x 50 mm

• Recommended Flow Rate: 80–140 mL/min

• Column Hardware: Stainless Steel

• Brand: Cogent

Special Order Item Information

• Please review the Special Order Item Information for complete details.

• For pricing confirmation, availability, lead times, or application assistance, please contact MICROSOLV Customer Service.

Important Notes

• Suitable for reversed-phase chromatography

• USP L11 equivalent chemistry

• Fully double end-capped stationary phase

• Wide pore design improves accessibility for larger molecules

• Excellent for purification of peptides, natural products, APIs, and other large aromatic compounds

• High loading capacity for process-scale applications

• Typical operating range is approximately 80–140 mL/min

• Requires a specialized process HPLC system

• Short 50 mm length helps reduce run times and solvent consumption

• Well suited for process development, scale-up, and production chromatography

• This is a Special Order Item