Catalog Number - 68524-P50-1003M

Cogent RP Phenyl™ Wide Pore Process HPLC Columns are designed for high-capacity purification, process development, and production-scale chromatography involving larger aromatic compounds and structurally related analytes. Manufactured using ultra-high purity silica bonded with a three-carbon linker and terminal Phenyl functionality, this stationary phase is fully double end-capped to minimize secondary interactions and provide highly reproducible chromatographic performance. The 300Å wide pore structure improves accessibility for larger molecules while maintaining the aromatic selectivity characteristic of RP Phenyl™ chemistry.

68524-P50-1003M is packed with 5 µm RP Phenyl™ Wide Pore particles featuring a 300Å pore size in a 50 mm ID x 100 mm process-scale format. The 5 µm particle size performs well at elevated process flow rates while maintaining moderate operating backpressure. The large internal diameter provides substantial sample loading capacity, making this column ideal for high-throughput purification, process development, and manufacturing-scale chromatographic applications.

The 50 mm ID x 100 mm format is particularly well suited for purification of larger positional isomers, tocopherols, flavonoids, polynuclear aromatic hydrocarbons, nitro-aromatic compounds, active pharmaceutical ingredients (APIs), natural products, peptides, and related compounds containing aromatic structures. Typical operating flow rates are approximately 80–140 mL/min depending on mobile phase composition, system pressure limitations, and application requirements. A process-scale HPLC system capable of supporting these flow rates and sample loads is required.

Key Benefits

• RP Phenyl™ Wide Pore stationary phase

• USP L11 equivalent chemistry

• Ultra-high purity silica support

• Fully double end-capped

• Phenyl bonded phase

• 300Å pore size

• Suitable for reversed-phase chromatography

• Enhanced aromatic selectivity

• Improved accessibility for larger molecules

• High sample loading capacity

Typical Applications

• Process HPLC

• Production-scale purification

• Large positional isomer separations

• Tocopherol purification

• Flavonoid purification

• Polynuclear aromatic hydrocarbon separations

• Nitro-aromatic compound purification

• Active pharmaceutical ingredient (API) purification

• Natural product isolation

• Process development and scale-up

Specifications

• Product Type: Process HPLC Column

• Stationary Phase: RP Phenyl™ Wide Pore

• Chromatography Mode: Reversed Phase

• USP Classification: L11

• Particle Size: 5 µm

• Pore Size: 300Å

• Column Dimensions: 50 mm ID x 100 mm

• Recommended Flow Rate: 80–140 mL/min

• Column Hardware: Stainless Steel

• Brand: Cogent

Special Order Item Information

• Please review the Special Order Item Information for complete details.

• For pricing confirmation, availability, lead times, or application assistance, please contact MICROSOLV Customer Service.

Important Notes

• Suitable for reversed-phase chromatography

• USP L11 equivalent chemistry

• Fully double end-capped stationary phase

• Wide pore design improves accessibility for larger molecules

• Excellent for purification of peptides, natural products, APIs, and other large aromatic compounds

• High loading capacity for process-scale applications

• Typical operating range is approximately 80–140 mL/min

• Requires a specialized process HPLC system

• Well suited for process development, scale-up, and production chromatography

• This is a Special Order Item