Catalog Number - 68512-SP-PG1

Cogent RP C12™ Semi-Preparative Guard Column Cartridges are designed to protect valuable semi-preparative HPLC columns from particulates, strongly retained compounds, and sample contaminants that can reduce column performance and shorten column life. Packed with the same RP C12™ stationary phase used in Cogent semi-preparative columns, these guard cartridges help maintain chromatographic consistency while extending column service life. The stationary phase is manufactured using a rigid adamantane-shaped carbon silane ligand bonded to ultra-high purity silica and fully double end capped to provide reproducible reversed-phase performance and rapid equilibration.

68512-SP-PG1 is a semi-preparative guard column cartridge packed with 5 µm RP C12™ particles featuring a 100 Å pore size in a 10 mm ID x 10 mm format. Designed specifically to protect RP C12™ semi-preparative columns, these cartridges capture particulates and contaminants before they reach the primary column bed. The unique RP C12™ chemistry provides selectivity between traditional C8 and C18 phases while maintaining compatibility with highly aqueous mobile phases, including 100% water. Constructed from stainless steel tubing with stainless steel frits, they provide durability and reliable performance in purification, fraction collection, and scale-up applications.

Routine replacement of guard cartridges helps maintain column efficiency, preserve chromatographic performance, and reduce the cost of replacing larger semi-preparative columns. These cartridges are particularly beneficial for compound purification, method development, fraction collection, and analytical-to-semi-preparative scale-up workflows.

Key Benefits

• RP C12™ stationary phase

• Adamantane-shaped bonded ligand

• Fully double end capped

• Ultra-high purity silica support

• 100 Å pore size

• Protects semi-preparative HPLC columns

• Extends column lifetime

• Maintains chromatographic performance

• Compatible with 100% aqueous mobile phases

• Supplied in convenient 5-pack format

Typical Applications

• Semi-preparative HPLC

• Compound purification

• Fraction collection

• Method scale-up

• Process development

• Pharmaceutical purification

• Natural product isolation

• Complex mixture separations

• Research and development

• Column protection

Specifications

• Product Type: Semi-Preparative Guard Column Cartridge

• Stationary Phase: RP C12™

• Chromatography Mode: Reversed Phase

• Bonded Phase: Adamantane-Shaped C12 Ligand

• Endcapping: Fully Double End Capped

• Particle Size: 5 µm

• Pore Size: 100 Å

• Cartridge Dimensions: 10 mm ID x 10 mm

• Construction: Stainless Steel Tube with Stainless Steel Frits

• Quantity: 5/PK

• Brand: Cogent

Special Order Item Information

• Please review the Special Order Item Information for complete details.

• For pricing confirmation, availability, lead times, or application assistance, please contact MICROSOLV Customer Service.

Important Notes

• Designed to protect RP C12™ semi-preparative HPLC columns from particulates and contaminants

• Helps extend column service life and maintain chromatographic performance

• Provides a selectivity profile between traditional C8 and C18 phases

• Compatible with highly aqueous and 100% water mobile phases

• Suitable for purification and scale-up workflows

• Constructed with durable stainless steel hardware

• A Cogent Guard Column Holder is required for use with these guard column cartridges

• Compatible with Cogent RP C12™ 10 mm ID semi-preparative columns

• Helps reduce the cost of replacing larger semi-preparative columns

• Supplied as a package of five replacement cartridges

• This is a Special Order Item