Catalog Number - 68512-P30-50

Cogent RP C12™ Preparative HPLC Columns are designed for purification, scale-up, and preparative chromatography applications requiring unique selectivity, rapid equilibration, and reproducible retention. The stationary phase is manufactured using a rigid adamantane-shaped carbon silane ligand bonded to ultra-high purity silica and fully double end capped to minimize secondary interactions. This distinctive bonded phase chemistry offers chromatographic behavior between traditional C8 and C18 phases, making it especially useful for preparative separations of complex mixtures and compounds where alternative selectivity is beneficial.

68512-P30-50 is packed with 5 µm RP C12™ particles featuring a 100 Å pore size in a 30 mm ID x 50 mm preparative format. The large internal diameter provides very high sample loading capacity for purification and fraction collection, while the shorter column length reduces run times and solvent consumption. The RP C12™ phase typically provides less retention than C18 columns but greater retention than C8 columns for many hydrophobic compounds, offering unique selectivity that can improve preparative separations. The stationary phase is also compatible with highly aqueous mobile phases, including 100% water, without phase collapse or loss of retention.

The 30 mm ID x 50 mm format is ideal for rapid preparative separations, purification screening, method scouting, and analytical-to-preparative method scale-up. Typical flow rates are approximately 30-50 mL/min depending on mobile phase composition, system pressure limitations, and application requirements. A specialized preparative HPLC system capable of high flow rates, large injection volumes, and substantial sample loading is required for optimum performance.

Key Benefits

• RP C12™ stationary phase

• Adamantane-shaped bonded ligand

• Fully double end capped

• Ultra-high purity silica support

• 100 Å pore size

• Unique selectivity profile

• Compatible with 100% aqueous mobile phases

• Rapid equilibration between runs

• Very high sample loading capacity

• Fast preparative run times

Typical Applications

• Preparative HPLC

• Compound purification

• Fraction collection

• Method scouting

• Method scale-up

• Pharmaceutical purification

• Natural product isolation

• Process development

• Production-scale chromatography

• Alternative selectivity applications

Specifications

• Product Type: Preparative HPLC Column

• Stationary Phase: RP C12™

• Chromatography Mode: Reversed Phase

• Bonded Phase: Adamantane-Shaped C12 Ligand

• Endcapping: Fully Double End Capped

• Particle Size: 5 µm

• Pore Size: 100 Å

• Column Dimensions: 30 mm ID x 50 mm

• Recommended Flow Rate: 30-50 mL/min

• Column Hardware: Stainless Steel

• Brand: Cogent

Special Order Item Information

• Please review the Special Order Item Information for complete details.

• or pricing confirmation, availability, lead times, or application assistance, please contact MICROSOLV Customer Service.

Important Notes

• Designed for preparative reversed-phase purification

• Provides a selectivity profile between traditional C8 and C18 phases

• Compatible with highly aqueous and 100% water mobile phases

• Rapid equilibration minimizes preparation time between runs

• Suitable for hydrophobic and moderately non-polar compounds

• 30 mm ID format provides very high sample loading capacity

• Short 50 mm length minimizes run times and solvent consumption

• 5 µm particles support preparative flow rates with manageable backpressure

• Typical operating range is approximately 30-50 mL/min

• Requires a specialized preparative HPLC system capable of high flow rates and substantial sample loading

• Suitable for analytical-to-preparative method scale-up

• This is a Special Order Item

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