Catalog Number - 68512-P21-PG1

Cogent RP C12™ Preparative Guard Column Cartridges are designed to protect valuable preparative HPLC columns from particulates, strongly retained compounds, and sample contaminants that can reduce column performance and shorten column life. Packed with the same RP C12™ stationary phase used in Cogent preparative columns, these guard cartridges help maintain chromatographic consistency while extending column service life. The stationary phase is manufactured using a rigid adamantane-shaped carbon silane ligand bonded to ultra-high purity silica and fully double end capped to provide reproducible reversed-phase performance and rapid equilibration.

68512-P21-PG1 is a preparative guard column cartridge packed with 5 µm RP C12™ particles featuring a 100 Å pore size in a 21.2 mm ID x 10 mm format. Designed specifically to protect RP C12™ preparative columns, this cartridge captures particulates and contaminants before they reach the primary column bed. The unique RP C12™ chemistry provides selectivity between traditional C8 and C18 phases while maintaining compatibility with highly aqueous mobile phases, including 100% water. Constructed from stainless steel tubing with stainless steel frits, it provides durability and reliable performance in preparative purification workflows.

Routine replacement of guard cartridges helps maintain column efficiency, preserve chromatographic performance, and reduce the cost of replacing larger preparative columns. These cartridges are particularly beneficial for compound isolation, fraction collection, process development, and analytical-to-preparative method scale-up where protecting the preparative column is essential.

Key Benefits

• RP C12™ stationary phase

• Adamantane-shaped bonded ligand

• Fully double end capped

• Ultra-high purity silica support

• 100 Å pore size

• Protects preparative HPLC columns

• Extends column lifetime

• Maintains chromatographic performance

• Compatible with 100% aqueous mobile phases

• Durable stainless steel construction

Typical Applications

• Preparative HPLC

• Compound purification

• Fraction collection

• Method scale-up

• Process development

• Pharmaceutical purification

• Natural product isolation

• Pilot-scale chromatography

• Complex mixture separations

• Column protection

Specifications

• Product Type: Preparative Guard Column Cartridge

• Stationary Phase: RP C12™

• Chromatography Mode: Reversed Phase

• Bonded Phase: Adamantane-Shaped C12 Ligand

• Endcapping: Fully Double End Capped

• Particle Size: 5 µm

• Pore Size: 100 Å

• Cartridge Dimensions: 21.2 mm ID x 10 mm

• Construction: Stainless Steel Tube with Stainless Steel Frits

• Quantity: 1 EA

• Brand: Cogent

Special Order Item Information

• Please review the Special Order Item Information for complete details.

• For pricing confirmation, availability, lead times, or application assistance, please contact MICROSOLV Customer Service.

Important Notes

• Designed to protect RP C12™ preparative HPLC columns from particulates and contaminants

• Helps extend preparative column service life and maintain chromatographic performance

• Provides a selectivity profile between traditional C8 and C18 phases

• Compatible with highly aqueous and 100% water mobile phases

• Suitable for purification and scale-up workflows

• Constructed with durable stainless steel hardware

• A specialized preparative HPLC system is required for columns of this size

• A Cogent 21.2 mm ID Preparative Guard Column Holder (83000-P21-GH) is required for use with this guard column cartridge

• Compatible with Cogent RP C12™ 21.2 mm ID preparative columns

• Helps reduce the cost of replacing larger preparative columns

• This is a Special Order Item