Catalog Number - 68508-P50-250

Cogent RP C8™ Process HPLC Columns are designed for large-scale purification and process chromatography applications using a traditional octyl (C8) bonded stationary phase. Manufactured with ultra-high purity silica and fully double end capped bonding technology, these columns provide reproducible retention, excellent peak shape, and long service life under demanding process-scale operating conditions. The RP C8™ phase offers lower hydrophobic retention than comparable C18 phases while maintaining excellent selectivity for hydrophobic and neutral compounds commonly encountered in purification workflows.

68508-P50-250 is packed with 5 µm RP C8™ particles featuring a 100 Å pore size in a 50 mm ID x 250 mm length process-scale format. The extended column length provides maximum resolving power and purification efficiency, while the large internal diameter delivers exceptionally high sample loading capacity for demanding production-scale separations. This configuration is ideal for compound isolation, fraction collection, process development, and manufacturing-scale purification. The RP C8™ stationary phase is particularly useful for hydrophobic compounds, neutral analytes, and long-chain fatty acids where lower retention than a comparable C18 phase is desired.

The 50 mm ID x 250 mm format is intended for process chromatography, pilot production, and large-scale manufacturing operations where the highest purification capacity and chromatographic resolution are required. Typical flow rates are approximately 80-140 mL/min depending on mobile phase composition, system pressure limitations, and application requirements. A specialized process HPLC system capable of high flow rates, large injection volumes, and substantial sample loading is required for optimum performance.

Key Benefits

• RP C8™ stationary phase

• Octyl (C8) bonded phase

• Fully double end capped

• Ultra-high purity silica support

• 100 Å pore size

• Exceptionally high sample loading capacity

• Maximum purification efficiency

• Lower retention than C18 phases

• Designed for process-scale purification

• Supports high flow rate operation

Typical Applications

• Process HPLC

• Large-scale compound purification

• Production-scale separations

• Fraction collection

• Method scale-up

• Pharmaceutical purification

• Natural product isolation

• Long-chain fatty acid purification

• Hydrophobic compound purification

• Manufacturing applications

Specifications

• Product Type: Process HPLC Column

• Stationary Phase: RP C8™

• Chromatography Mode: Reversed Phase

• Bonded Phase: Octyl (C8)

• Endcapping: Fully Double End Capped

• Particle Size: 5 µm

• Pore Size: 100 Å

• Column Dimensions: 50 mm ID x 250 mm

• Recommended Flow Rate: 80-140 mL/min

• Column Hardware: Stainless Steel

• Brand: Cogent

Special Order Item Information

• Please review the Special Order Item Information for complete details.

• For pricing confirmation, availability, lead times, or application assistance, please contact MICROSOLV Customer Service.

Important Notes

• Designed for process-scale reversed-phase purification

• Provides lower retention than comparable C18 columns

• Suitable for hydrophobic and moderately non-polar compounds

• Excellent choice for large-scale compound isolation and purification

• 50 mm ID format provides exceptionally high sample loading capacity

• 250 mm length provides maximum resolving power and purification efficiency

• 5 µm particles support high flow rates with manageable backpressure

• Typical operating range is approximately 80-140 mL/min

• Requires a specialized process HPLC system capable of high flow rates and substantial sample loading

• Suitable for preparative-to-process method scale-up

• This is a Special Order Item