Catalog Number - 68508-P21-50

Cogent RP C8™ Preparative HPLC Columns are designed for purification and scale-up applications using a traditional octyl (C8) bonded stationary phase. Manufactured with ultra-high purity silica and fully double end capped bonding technology, these columns provide reproducible retention, excellent peak shape, and long service life under preparative operating conditions. The RP C8™ phase offers lower hydrophobic retention than comparable C18 phases while maintaining excellent selectivity for hydrophobic and neutral compounds commonly encountered in purification workflows.

68508-P21-50 is packed with 5 µm RP C8™ particles featuring a 100 Å pore size in a 21.2 mm ID x 50 mm length preparative format. The large internal diameter provides substantial sample loading capacity while the shorter column length minimizes run times and solvent consumption. This configuration is ideal for rapid preparative separations, method scouting, purification screening, and analytical-to-preparative method transfer. The RP C8™ stationary phase is particularly useful for hydrophobic compounds, neutral analytes, and long-chain fatty acids where lower retention than a comparable C18 phase is desired.

The 21.2 mm ID format is commonly used for preparative purification and scale-up applications. Typical flow rates are approximately 15-25 mL/min depending on mobile phase composition and system configuration. A specialized preparative HPLC system capable of delivering higher flow rates, larger injection volumes, and increased sample loading is required for optimum performance.

Key Benefits

• RP C8™ stationary phase

• Octyl (C8) bonded phase

• Fully double end capped

• Ultra-high purity silica support

• 100 Å pore size

• High sample loading capacity

• Lower retention than C18 phases

• Fast preparative run times

• Designed for purification workflows

• Suitable for scale-up applications

Typical Applications

• Preparative HPLC

• Compound purification

• Fraction collection

• Method scouting

• Method scale-up

• Pharmaceutical purification

• Natural product isolation

• Long-chain fatty acid purification

• Hydrophobic compound purification

• Process development

Specifications

• Product Type: Preparative HPLC Column

• Stationary Phase: RP C8™

• Chromatography Mode: Reversed Phase

• Bonded Phase: Octyl (C8)

• Endcapping: Fully Double End Capped

• Particle Size: 5 µm

• Pore Size: 100 Å

• Column Dimensions: 21.2 mm ID x 50 mm

• Recommended Flow Rate: 15-25 mL/min

• Column Hardware: Stainless Steel

• Brand: Cogent

Special Order Item Information

• Please review the Special Order Item Information for complete details.

• For pricing confirmation, availability, lead times, or application assistance, please contact MICROSOLV Customer Service.

Important Notes

• Designed for preparative reversed-phase HPLC purification

• Provides lower retention than comparable C18 columns

• Suitable for hydrophobic and moderately non-polar compounds

• Excellent choice for compound isolation and fraction collection

• 21.2 mm ID format provides substantially increased sample loading capacity

• Short 50 mm length minimizes run times and solvent consumption

• 5 µm particles support preparative flow rates with manageable backpressure

• Typical operating range is approximately 15-25 mL/min

• Requires a specialized preparative HPLC system capable of higher flow rates and sample loads

• Suitable for analytical-to-preparative method scale-up

• This is a Special Order Item