Catalog Number - 68308-15P-4

Cogent RP C8 Octyl™ is a versatile reversed-phase HPLC stationary phase designed for the separation of hydrophobic and neutral compounds. Manufactured using a traditional octyl (C8) bonded phase on ultra-high purity silica and fully double end capped, it provides strong hydrophobic interactions while often offering reduced retention compared to C18 phases. As a USP L7 equivalent phase, it is widely used for method replacement, method development, and routine analytical separations where balanced retention and selectivity are desired.

68308-15P-4 is an HPLC column packed with 3 µm RP C8 Octyl™ particles featuring a 100 Å pore size in a 4.0 mm ID x 150 mm format. The 150 mm length provides increased resolution and peak capacity compared to shorter column formats, while the 3 µm particles deliver improved efficiency and sharper peaks than comparable 5 µm columns. Typical operating flow rates are approximately 0.8–1.5 mL/min depending on mobile phase composition, temperature, and system configuration.

This column is particularly useful for hydrophobic and neutral compounds in reversed-phase chromatography and is especially well suited for long-chain fatty acid analysis. The C8 chemistry offers excellent retention and selectivity while often reducing excessive retention compared to more hydrophobic phases. This format is an excellent choice for method development, impurity profiling, and applications requiring enhanced chromatographic resolution.

Key Benefits

• RP C8 Octyl™ stationary phase

• USP L7 equivalent chemistry

• Fully double end capped

• Traditional octyl (C8) bonded phase

• Ultra-high purity silica support

• 3 µm particle size

• Greater efficiency than 5 µm columns

• Increased peak capacity

• Enhanced chromatographic resolution

• Excellent for long-chain fatty acid analysis

Typical Applications

• USP L7 methods

• Reversed-phase HPLC

• Long-chain fatty acid analysis

• Hydrophobic compound analysis

• Neutral compound analysis

• Pharmaceutical analysis

• Method development

• Quality control testing

• Impurity profiling

• Routine analytical methods

Specifications

• Product Type: HPLC Column

• Stationary Phase: RP C8 Octyl™

• USP Classification: L7

• Chromatography Mode: Reversed Phase

• Bonded Phase: Octyl (C8)

• Endcapping: Fully Double End Capped

• Particle Size: 3 µm

• Pore Size: 100 Å

• Column Dimensions: 4.0 mm ID x 150 mm

• Length: 150 mm

• Typical Flow Rate: 0.8–1.5 mL/min

• Brand: Cogent

Special Order Item Information

• For complete details, please review the Special Order Item Information.

• For pricing confirmation, availability, lead times, or application assistance, please contact MICROSOLV Customer Service.

Important Notes

• Suitable for conventional HPLC systems

• 3 µm particles provide higher efficiency and sharper peaks than comparable 5 µm columns

• Generates higher backpressure than larger particle columns

• The 150 mm length provides greater resolution and peak capacity than shorter column formats

• Particularly useful for long-chain fatty acid separations

• Commonly used for hydrophobic and neutral compounds

• Often selected for method development and impurity profiling

• Frequently used as a replacement column for USP L7 methods

• Methods using viscous mobile phases may approach instrument pressure limits

• This is a Special Order Item