Process HPLC Column, RP Phenyl, 10um, 100A. 50mm ID x 250mm Length. Cogent Brand. 1 EA.
Additional Information:
Cogent RP Phenyl is MICROSOLV's most popular phenyl stationary phase for reversed-phase HPLC and LC-MS applications. Built on high-purity silica with a C3-phenyl bonded phase and exhaustive double endcapping, it combines hydrophobic retention with strong π-π interactions to provide enhanced selectivity for aromatic and structurally related compounds that may not separate sufficiently on traditional C18 or C8 columns.
68024-P50-250 is a process-scale HPLC column packed with 10 µm RP Phenyl particles featuring a 100 Å pore size in a 50 mm ID x 250 mm format. The large internal diameter provides very high sample loading capacity, while the 250 mm length maximizes resolving power and peak capacity for demanding production-scale separations. The 10 µm particle size supports high flow rates with lower operating backpressure, making this column suitable for process development, large-scale purification, and manufacturing workflows. Typical operating flow rates are approximately 80–200 mL/min depending on sample load, mobile phase composition, and system capabilities.
This column is particularly effective for purification of positional isomers, aromatic pharmaceuticals, tocopherols, flavonoids, polynuclear aromatic compounds, nitro-aromatic compounds, active pharmaceutical ingredients (APIs), natural products, and related aromatic compounds. The RP Phenyl chemistry provides a scalable path from analytical method development through preparative chromatography to full process-scale production.
Key Benefits
RP Phenyl stationary phase with C3-phenyl bonded chemistry
Strong π-π interaction selectivity
High-purity silica support
Fully double endcapped
Reduced silanol activity
Reduced peak tailing
Excellent peak symmetry
Very high loading capacity
Ideal for aromatic and phenyl-containing compounds
Scalable from analytical to process chromatography
Typical Applications
Process HPLC purification
Large-scale fraction collection
Positional isomer purification
Aromatic pharmaceutical purification
Active pharmaceutical ingredient (API) purification
Tocopherol purification
Flavonoid purification
Polynuclear aromatic compound purification
Natural product isolation
Production-scale chromatography
Specifications
Product Type: Process HPLC Column
Stationary Phase: RP Phenyl
Chromatography Mode: Reversed Phase
Bonded Phase: C3-Phenyl
Endcapping: Fully Double Endcapped
Particle Size: 10 µm
Pore Size: 100 Å
Column Dimensions: 50 mm ID x 250 mm
Length: 250 mm
Typical Flow Rate: 80–200 mL/min
Brand: Cogent
Additional Resources
Special Order Item Information
Important Notes
Designed for process-scale purification and production workflows
Often selected when C18 or C8 phases do not provide adequate selectivity
Strong π-π interactions can improve separation of aromatic compounds
Extended column length maximizes resolving power for challenging purifications
Requires a specialized process HPLC system capable of high flow rates and large-volume fraction collection