Catalog Number - 68018-P21-PG1

Cogent RP C18™ Preparative Guard Column Cartridges are designed to protect valuable preparative HPLC columns from particulate matter, strongly retained contaminants, and sample matrix components that can shorten column life and reduce chromatographic performance. Packed with high-purity silica bonded with a traditional C18 (octadecyl) ligand and fully double end-capped chemistry, these guard cartridges provide the same chromatographic selectivity as the preparative column they protect while helping maintain purification efficiency and reproducible results.

68018-P21-PG1 is packed with 10 µm RP C18™ particles in a 21.2 mm ID x 10 mm preparative guard cartridge format. Housed in stainless steel hardware with stainless steel frits, the cartridge is installed ahead of the preparative column to trap particulates and strongly retained contaminants before they reach the primary column bed. This helps extend preparative column lifetime, reduce downtime, and lower operating costs in demanding purification environments.

For many years, Cogent RP C18™ preparative columns and guard cartridges have been trusted by pharmaceutical, biotechnology, cannabis, chemical, food, and research laboratories worldwide. This guard cartridge is particularly valuable in purification workflows where protecting the preparative column helps maintain loading capacity, chromatographic efficiency, and purification performance throughout the life of the column.

Key Benefits

• RP C18™ stationary phase

• USP L1 equivalent chemistry

• Fully double end-capped

• High-purity silica support

• Traditional C18 bonded phase

• 100Å pore size

• 10 µm particle size

• Protects preparative columns from contamination

• Helps extend column life

• Maintains chromatographic performance

Typical Applications

• Preparative HPLC

• Column protection

• Compound purification

• Pharmaceutical purification

• Cannabis purification

• Biotechnology applications

• Reversed-phase chromatography

• Method development

• Process scale-up

• Research laboratories

Specifications

• Product Type: Preparative Guard Column Cartridge

• Stationary Phase: RP C18™

• USP Classification: L1

• Chromatography Mode: Reversed Phase

• Particle Size: 10 µm

• Pore Size: 100Å

• Cartridge Dimensions: 21.2 mm ID x 10 mm

• Hardware Material: Stainless Steel

• Frit Material: Stainless Steel

• Brand: Cogent

Guard Column Holder Required

• Requires the Cogent 21.2 mm ID Preparative Guard Column Holder (83000-P21-GH) for installation and operation.

Important Notes

• USP L1 equivalent stationary phase

• Fully double end-capped C18 bonded phase

• Manufactured using high-purity silica

• Designed to protect RP C18™ preparative columns from particulates and strongly retained contaminants

• Helps extend preparative column service life

• Maintains chromatographic performance and reproducibility

• Recommended for purification and preparative workflows

• Compatible with Cogent 21.2 mm ID RP C18™ preparative columns

• Requires the Cogent 21.2 mm ID Preparative Guard Column Holder (83000-P21-GH)

• Suitable for high-loading preparative chromatography applications

• Requires a preparative HPLC system designed for larger diameter columns

Special Order Item Information

• Please review the Special Order Item Information for complete details.

• For pricing confirmation, availability, lead times, or application assistance, please contact MICROSOLV Customer Service.

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