Semi Prep HPLC Column, RP C8 Octyl, 10um, 100A. 10mm ID x 250mm Length. Cogent Brand. 1 EA.
Additional Information:
Cogent RP C8 Octyl is a reversed-phase semi-preparative HPLC stationary phase manufactured using high-purity silica with traditional octyl (C8) silane bonding and complete double endcapping. The moderate hydrophobicity of the C8 ligand provides lower retention than C18 phases while maintaining effective retention of hydrophobic and neutral compounds. This selectivity makes the phase well suited for semi-preparative purification workflows where compound recovery, throughput, and efficient fraction collection are important.
68008-SP250 is a semi-preparative HPLC column with dimensions of 10 mm ID x 250 mm length, packed with 10 µm RP C8 Octyl particles featuring a 100 Å pore size. The 10 mm internal diameter provides significantly greater sample loading capacity than analytical columns, while the 250 mm length offers maximum resolving power and peak capacity for purification of closely related compounds. The 10 µm particle size supports higher flow rates with lower operating backpressure, making this column suitable for purification, method transfer, and scale-up workflows. Typical operating flow rates are approximately 8–15 mL/min depending on sample load, mobile phase composition, and system capabilities.
Designed for purification and fraction collection rather than routine analytical HPLC, this column is ideal for isolating hydrophobic or neutral compounds in pharmaceutical research, synthetic chemistry, natural product purification, reference standard preparation, and process development applications. The extended column length can significantly improve separation and purity during compound isolation workflows. Analytical methods are commonly developed on analytical columns before being transferred and optimized on semi-preparative columns such as this one. A semi-preparative HPLC system capable of higher flow rates, larger injection volumes, and fraction collection is required. This product is supplied as a Special Order Item manufactured specifically upon receipt of order.
Key Benefits
RP C8 Octyl stationary phase
Fully double endcapped chemistry
Traditional octyl (C8) bonded phase
Designed for semi-preparative HPLC purification
Increased sample loading capacity
Lower retention than C18 phases
10 µm particles for lower operating backpressure
Suitable for higher semi-preparative flow rates
Maximum resolution with 250 mm length
Ideal for purification and fraction collection
Typical Applications
Semi-preparative HPLC purification
Fraction collection
Compound isolation
Pharmaceutical research
Synthetic chemistry
Natural product purification
Reference standard preparation
Process development
Method scale-up
Production support purification
Specifications
Product Type: Semi-Preparative HPLC Column
Stationary Phase: RP C8 Octyl
Chromatography Mode: Reversed Phase
Bonded Phase: Octyl (C8)
Endcapping: Fully Double Endcapped
Particle Size: 10 µm
Pore Size: 100 Å
Column Dimensions: 10 mm ID x 250 mm
Length: 250 mm
Typical Flow Rate: 8–15 mL/min
Brand: Cogent
Special Order Item Information
Important Notes
Intended for purification and fraction collection rather than routine analytical HPLC
Increased loading capacity compared to analytical columns
Extended column length can improve purification of closely related compounds
Analytical methods are often developed on analytical columns before transfer to semi-preparative columns
Requires a semi-preparative HPLC system capable of higher flow rates and fraction collection
Provides less retention than comparable C18 phases
Special Order Item