Catalog Number - 70000-P30-150

The 70000‑P30‑150 Diamond Hydride Preparative HPLC Column is engineered for resolution‑critical, process‑scale purification where shorter preparative columns do not provide sufficient separation. This extended‑length, large‑diameter column increases resolving power while maintaining the high sample capacity required for downstream research, development, or commercial workflows.

Preparative Use Case: Why 30 mm ID × 150 mm

The 30 mm internal diameter defines this column as process‑scale preparative, intended for laboratories performing large‑volume injections and collecting substantial quantities of purified analytes.

The 150 mm column length provides meaningful chromatographic advantages:

• Increased theoretical plate count versus 50 mm and 100 mm process columns

• Improved resolution of closely eluting or structurally similar compounds

• Greater peak capacity for complex polar mixtures

• Higher confidence during high‑value fraction collection

This configuration is typically selected when resolution is a primary requirement, but a full 250 mm preparative column is unnecessary or inefficient for the application.

Diamond Hydride™ TYPE‑C Stationary Phase Advantages

Manufactured using Cogent TYPE‑C™ silica hydride technology, the Diamond Hydride stationary phase delivers stable, reproducible performance for demanding preparative HILIC separations:

• Highly consistent retention of polar and basic analytes

• Faster equilibration than conventional bonded‑silica HILIC phases

• Excellent chemical stability under high‑organic mobile‑phase conditions

• Extended column lifetime in continuous or repeated purification processes

This chemistry is particularly effective for purification of:

• Peptides and peptide‑like compounds

• Metabolites and highly polar small molecules

• Amine‑containing and basic analytes

• Targets best isolated using HILIC‑based retention mechanisms

Purpose‑Built for Resolution‑Focused Process Purification

The 70000‑P30‑150 supports predictable scale‑up from smaller preparative formats while preserving chromatographic behavior. It is frequently used in process development, pilot‑scale purification, and production‑support environments where separation quality cannot be compromised, yet practical throughput must be maintained.

System Requirements

Typical operating flow rates: ~40–70 mL/min

This column requires a dedicated preparative or process‑scale HPLC system capable of:

• Sustained high‑flow solvent delivery

• Large injection volumes

• Pressure limits appropriate for longer preparative columns

• Suitable detector configurations and fraction collection hardware

Analytical and semi‑preparative HPLC systems are not suitable for 30 mm ID preparative columns.

Flow rates should be optimized based on mobile‑phase composition, solvent viscosity, pressure limits, and purification objectives.

Made‑to‑Order Columns & Pricing Information

These columns represent a significant investment and are often application‑specific. To ensure customers receive the correct column for their workflow:

• Pricing and technical support are provided through our Customer Service Department via formal quotation

• Columns are produced on order, based on customer requirements

• Orders cannot be canceled or returned once placed

• Learn more about Custom Orders and our Custom Order policies.