Catalog Number - 70000-7.5P

Short‑Length Diamond Hydride™ Performance for Fast, Efficient HPLC

The 70000‑7.5P Diamond Hydride™ HPLC Column is a custom‑manufactured analytical column designed for laboratories seeking rapid HILIC separations, reduced analysis time, and lower system backpressure. Built on Cogent TYPE‑C™ silica hydride technology, this 4.6 mm ID × 75 mm length column delivers fast equilibration, stable retention, and excellent selectivity for polar compounds using conventional HPLC instrumentation.

Although the 75 mm length is less commonly used than standard 100 or 150 mm columns, it provides distinct advantages for high‑throughput and screening workflows where speed and robustness are prioritized over maximum resolving power.

Why the 75 mm Length Can Be Advantageous

The 4.6 mm × 75 mm configuration is intentionally selected for applications that benefit from:

• Shorter run times and increased sample throughput

• Reduced column backpressure compared to longer analytical columns

• Faster equilibration during method development and screening

• Lower overall solvent consumption per analysis

For many laboratories, this format is ideal when target analytes are well separated under HILIC conditions and full 150 mm resolution is not required.

Diamond Hydride™ Stationary Phase Advantage

Manufactured using Cogent TYPE‑C™ silica hydride technology, the Diamond Hydride™ stationary phase offers core benefits over conventional bonded‑silica HILIC materials:

• Rapid equilibration between injections

• Stable and reproducible retention mechanisms at high organic content

• Mixed‑mode interaction capability for challenging polar analytes

• Extended column lifetime suitable for routine and validated workflows

These characteristics make Diamond Hydride™ columns reliable tools for both fast analyses and longer analytical campaigns.

Ideal Applications

The 70000‑7.5P Diamond Hydride column is commonly used for:

• Small, highly polar molecules

• Amino acids and organic acids

• Polar and moderately non‑polar peptides

• Metabolites and other biologically relevant compounds

It is particularly effective in screening, method development, and time‑sensitive workflows.

Fast HPLC and UV Detection

The reduced column length enables rapid separation while maintaining consistent peak shape and reproducibility, making this column well‑suited for:

• Fast analysis of very polar compounds using UV detection

• High‑throughput assays and sample screening

• Applications where speed and robustness outweigh maximum resolution needs

Because of its standard 4.6 mm internal diameter, the column supports traditional injection volumes and detector configurations without specialized hardware.

LC‑MS Compatibility

Although optimized for conventional HPLC workflows, the 70000‑7.5P is fully compatible with LC‑MS applications where standard analytical flow operation is acceptable, or where post‑column flow splitting is employed in HILIC‑based methods.

Operating Guidelines and System Requirements

• Typical flow‑rate range: ~0.8–1.5 mL/min (method‑ and solvent‑dependent)

• System compatibility: All conventional analytical HPLC systems

• Special requirements: No low‑flow capability required

Flow rates may be adjusted to balance speed, pressure limits, and resolution targets.

Custom Item Notice

This product is classified as a Custom Item. Custom items are made to order, non‑returnable, and cannot be canceled once production begins.

• Learn more about Custom Orders and our Custom Order policies.