Prep HPLC Column, Phenyl Hydride, 4um, 100A. 21.2mm ID x 250mm Length, Preparative. Cogent TYPE-C Brand. 1 EA.
Additional Info:
Maximum‑Resolution Preparative HILIC Purification with Aromatic Selectivity Using Phenyl Hydride™
The 69020‑P21‑250 Phenyl Hydride™ Prep HPLC Column is designed for laboratories performing maximum‑resolution preparative‑scale purification of aromatic and polar compounds. Manufactured with Cogent TYPE‑C™ silica hydride technology, the Phenyl Hydride stationary phase provides excellent selectivity, reliable retention, and robust column lifetime under demanding preparative conditions.
This column is selected when closely related compounds require the highest possible separation or when extended retention improves purity and fraction discrimination during preparative HILIC workflows.
Why Choose Phenyl Hydride™ for High‑Resolution Preparative HILIC
Phenyl Hydride™ stationary phases offer interaction mechanisms particularly effective for preparative purification involving aromatic functionality:
Strong retention of polar compounds under HILIC conditions
π–π and hydrophobic interactions that enhance separation of aromatic species
Improved purification of structurally similar or closely eluting compounds
Stable, reproducible retention across repeated high‑load injections
These attributes support consistent fraction collection and high‑confidence isolation during scale‑up.
Cogent TYPE‑C™ Silica Hydride Advantage
Phenyl Hydride™ preparative columns are based on silica hydride surfaces rather than traditional silanol‑rich silica, delivering important benefits for long‑bed‑length operation:
Faster equilibration between runs compared to bonded‑silica HILIC materials
Stable retention at high organic mobile‑phase composition
Reduced stationary‑phase degradation under repeated preparative loading
Long column lifetime suitable for extended purification campaigns
These characteristics help minimize downtime and improve throughput.
Ideal Applications
The 69020‑P21‑250 Phenyl Hydride prep column is routinely used for purification of:
Aromatic amines
Small peptides containing aromatic residues
Azides and heteroaromatic compounds
Polar analytes requiring extended retention and maximum separation prior to isolation
It is particularly valuable when purity and separation confidence take precedence over run time.
21.2 mm ID × 250 mm Length for Maximum Preparative Separation
The 21.2 mm ID × 250 mm length configuration provides:
Maximum bed length and plate count for difficult separations
Extended retention for challenging polar analytes
Improved resolution of closely related compounds in complex mixtures
This format is typically chosen when shorter preparative columns do not provide adequate separation.
System Requirements and Operating Considerations
Intended use: Preparative‑scale HPLC purification
System requirement: A specialized preparative HPLC system capable of delivering higher flow rates and accommodating large column volumes
Detection: UV detection commonly employed; detector flow cells must be compatible with preparative flow rates
Standard analytical HPLC systems are not suitable for columns of this size.
Custom Item Notice
This product is classified as a Custom Item and can be manufactured to order. Custom Items are non‑returnable and cannot be canceled once an order has been placed.