Catalog Number - 69020-P21-150

High‑Resolution Preparative HILIC Purification with Aromatic Selectivity Using Phenyl Hydride™

The 69020‑P21‑150 Phenyl Hydride™ Prep HPLC Column is designed for laboratories performing high‑resolution preparative‑scale purification of aromatic and polar compounds. Manufactured with Cogent TYPE‑C™ silica hydride technology, the Phenyl Hydride stationary phase delivers excellent selectivity, fast equilibration, and robust column lifetime under demanding preparative operating conditions.

This column is commonly selected when greater resolving power is required than shorter preparative columns can provide, particularly for closely related compounds that are difficult to separate using reversed‑phase methods.

Why Choose Phenyl Hydride™ for Preparative HILIC

Phenyl Hydride™ stationary phases provide interaction mechanisms well suited to preparative HILIC workflows involving aromatic functionality:

• Strong retention of polar compounds under HILIC conditions

• π–π and hydrophobic interactions that enhance separation of aromatic species

• Improved resolution for structurally similar target compounds

• Stable and reproducible retention across repeated preparative injections

These features support consistent fraction collection and improved purity during scale‑up and routine purification.

Cogent TYPE‑C™ Silica Hydride Advantage

Phenyl Hydride™ prep columns are based on silica hydride surfaces rather than traditional silanol‑rich silica, delivering important advantages for preparative use:

• Faster equilibration between runs compared to bonded‑silica HILIC phases

• Stable retention at high organic mobile‑phase content

• Reduced stationary‑phase deterioration under repeated high‑load injections

• Long column lifetime suitable for routine purification campaigns

These characteristics help reduce downtime and improve productivity in preparative laboratories.

Ideal Applications

The 69020‑P21‑150 Phenyl Hydride prep column is routinely used for purification of:

• Aromatic amines

• Small peptides containing aromatic residues

• Azides and heteroaromatic compounds

• Polar analytes requiring enhanced preparative‑scale resolution

It is especially valuable when target compounds require maximum separation prior to isolation or downstream processing.

21.2 mm ID × 150 mm Length for Increased Preparative Resolution

The 21.2 mm ID × 150 mm length configuration provides:

• Increased bed length and plate count for improved separation

• Higher resolving power compared to 100 mm preparative columns

• Consistent performance for complex or closely related mixtures

This format is often chosen when resolution and purity take precedence over run time in preparative workflows.

System Requirements and Operating Considerations

• Intended use: Preparative‑scale HPLC purification

• System requirement: A specialized preparative HPLC system capable of delivering higher flow rates and accommodating large column volumes

• Detection: UV detection commonly employed; detector flow cells must be compatible with preparative flow rates

Standard analytical HPLC systems are not suitable for columns of this size.

Custom Item Notice

This product is classified as a Custom Item and can be manufactured to order. Custom Items are non‑returnable and cannot be canceled once an order has been placed.

• For additional details on our CUSTOM ITEM policy.