Prep HPLC Column, Phenyl Hydride, 4um, 100A. 21.2mm ID x 100mm Length, Preparative. Cogent TYPE-C Brand. 1 EA.
Additional Info:
Preparative‑Scale HILIC Purification with Aromatic Selectivity Using Phenyl Hydride™
The 69020‑P21‑100 Phenyl Hydride™ Prep HPLC Column is designed for laboratories performing preparative‑scale HILIC purification of aromatic and polar compounds. Manufactured with Cogent TYPE‑C™ silica hydride technology, the Phenyl Hydride stationary phase provides excellent selectivity, fast equilibration, and robust column lifetime under demanding preparative conditions.
This column is commonly selected when target compounds are difficult to retain or separate using reversed‑phase methods, and when reliable aromatic selectivity is required during purification.
Why Choose Phenyl Hydride™ for Preparative HILIC
Phenyl Hydride™ stationary phases offer interaction mechanisms well suited for preparative HILIC workflows:
Strong retention of polar analytes under HILIC conditions
π–π and hydrophobic interactions that enhance separation of aromatic species
Improved purification of structurally similar compounds
Stable, reproducible retention across multiple preparative injections
These properties support consistent fraction collection and improved purity during scale‑up.
Cogent TYPE‑C™ Silica Hydride Advantage
Phenyl Hydride™ prep columns are based on silica hydride surfaces rather than traditional silanol‑rich silica, providing important benefits for preparative use:
Faster equilibration between runs compared to bonded‑silica HILIC phases
Stable retention at high organic mobile‑phase content
Reduced phase degradation under repeated loading
Long column lifetime for routine purification workflows
These characteristics reduce downtime and improve throughput in preparative laboratories.
Ideal Applications
The 69020‑P21‑100 Phenyl Hydride prep column is routinely used for purification of:
Aromatic amines
Small peptides containing aromatic residues
Azides and heteroaromatic compounds
Polar analytes requiring preparative‑scale HILIC separation
It is especially effective when high selectivity is needed to resolve closely related compounds prior to isolation.
21.2 mm ID × 100 mm Length for Preparative Operation
The 21.2 mm ID × 100 mm length configuration is optimized for semi‑prep to preparative‑scale purification, offering:
Sufficient bed volume for higher sample loading
Efficient separations with manageable run times
Scalability from analytical method development
This format supports consistent performance during repeated purification cycles.
System Requirements and Operating Considerations
Intended use: Preparative HPLC purification
System requirement: A specialized preparative HPLC system capable of delivering higher flow rates and handling larger column volumes
Detection: UV commonly used; ensure detector flow cells are compatible with preparative flow rates
Standard analytical HPLC systems are not suitable for columns of this size.
Custom Item Notice
This product is classified as a Custom Item and can be manufactured to order. Custom Items are non‑returnable and cannot be canceled once an order has been placed.