Guard Column cartridge, UDC Cholesterol 2.o, replacement, 2.0 mm ID x 10 mm long cartridge packed with 2.2 um, 120 A phase. Cogent TYPE-C Brand. 1 EA.
Additional Info:
The 69269‑PG3 Cogent UDC‑Cholesterol 2.0 Guard Column Cartridge is a single replacement cartridge designed for UHPLC and high‑pressure analytical systems, providing essential protection while preserving shape‑selective chromatographic performance.
Each cartridge is:
2.0 mm ID × 10 mm length
Packed with 2.2 µm, 120 Å TYPE‑C™ silica hydride UDC‑Cholesterol 2.0 phase
Constructed in stainless steel housing with SS frits
The cartridge is supplied in an individual protective Delrin™ case, preventing contamination, drying, or physical damage prior to use.
⚠️ Requires guard column holder (sold separately)
Designed for 2.1 mm UHPLC Columns
This cartridge is optimized for:
2.1 mm ID UHPLC and analytical columns
Sub‑2 µm particle methods
LC‑MS workflows requiring high sensitivity
Proper guard column matching ensures:
Minimal band broadening despite small particle size
Maintained high efficiency and resolution
Consistent retention and selectivity
Why Use a Single Guard Cartridge
A single‑cartridge format is ideal when:
Evaluating different guard phases in method development
Using multiple analytical column chemistries
Replacing cartridges individually as needed
Maintaining flexibility without committing to multi‑packs
This provides maximum control and adaptability in UHPLC workflows.
Why Use UHPLC Guard Column Protection
Columns packed with 2.2 µm particles are highly sensitive to:
Particulate contamination
Strongly retained analytes
Sample matrix buildup
Pressure increases due to partial clogging
The 69269‑PG3 cartridge acts as a critical sacrificial protection layer, helping to:
Preserve UHPLC column efficiency and resolution
Prevent rapid backpressure increases
Extend column lifetime
Maintain consistent analytical performance
Cartridges can be replaced quickly without disturbing the analytical column.
UDC‑Cholesterol™ 2.0 Guard Phase Advantages
Matching the guard phase to the analytical column ensures:
Identical shape selectivity and retention behavior
No need for method re‑optimization
Seamless analyte transfer
Shape‑Selective Interaction
Separates compounds based on 3D molecular structure and steric fit
Ideal for isomers and structurally similar analytes
Strong Hydrophobic Retention
Effective for lipids and hydrophobic compounds
Tunable Selectivity
Adjust separations using:
Temperature changes
Mobile phase composition
Cogent TYPE‑C™ Technology Benefits
Silica Hydride Surface
Direct Si–C bonding (no end‑capping required)
Reduced silanol activity
Improved peak shape for basic and polar analytes
High‑Pressure Stability
Designed for UHPLC / sub‑2 µm applications
Compatible with elevated system pressures
Maintains performance under demanding conditions
Faster Equilibration
Reduced cycle times
Increased analytical throughput
Typical Applications
UHPLC and LC‑MS analytical workflows
Steroidal compound analysis
Structural isomer separations
Lipids and hydrophobic analytes
Peptides, proteins, and oligonucleotides
Methods requiring shape‑selectivity preservation