Guard Column cartridges, UDC Cholesterol 2.o, replacement, 2.0 mm ID x 10 mm long cartridges packed with 2.2 um, 120 A phase. Cogent TYPE-C Brand. 5/PK.
Additional Info:
The 69269‑PG2 Cogent UDC‑Cholesterol 2.0 Guard Column Cartridges are replacement cartridges engineered for UHPLC and high‑pressure analytical systems, providing critical protection while maintaining shape‑selective performance.
Each cartridge is:
2.0 mm ID × 10 mm length
Packed with 2.2 µm, 120 Å TYPE‑C™ silica hydride UDC‑Cholesterol 2.0 phase
Constructed in stainless steel housings with SS frits
Cartridges are individually packaged in protective Delrin™ cases, preventing contamination, drying, and damage prior to use.
⚠️ Requires guard column holder (sold separately)
Designed for 2.1 mm UHPLC Columns
These cartridges are optimized for:
2.1 mm ID UHPLC and analytical columns
Sub‑2 µm particle methods
LC‑MS workflows requiring high sensitivity
Proper guard column integration ensures:
Minimal band broadening
Maintained high efficiency and resolution
Consistent chromatographic performance
Why Use UHPLC Guard Cartridges
UHPLC columns using 2.2 µm particles are highly sensitive to:
Particulates and contamination
Strongly retained analytes
Sample matrix buildup
Pressure increases from partial blockages
The 69269‑PG2 cartridges act as a critical sacrificial protection layer, helping to:
Preserve UHPLC column efficiency and resolution
Prevent rapid pressure increases
Extend analytical column lifetime
Maintain reproducibility in high‑performance workflows
Cartridges can be replaced quickly without disturbing the analytical column.
UDC‑Cholesterol™ 2.0 Guard Phase Advantages
Using a matched guard phase ensures:
Identical shape selectivity and retention behavior
No change in method performance
Seamless analyte transfer to the analytical column
Shape‑Selective Interaction
Separates compounds based on 3D structure and steric fit
Ideal for isomers and structurally similar compounds
Strong Hydrophobic Retention
Effective for lipids and hydrophobic analytes
Tunable Selectivity
Adjust separations using:
Temperature changes
Mobile phase composition
Cogent TYPE‑C™ Technology Benefits
Silica Hydride Surface
Direct Si–C bonding (no end‑capping required)
Reduced silanol interactions
Improved peak shape for basic and polar analytes
High‑Pressure Stability
Designed for UHPLC / sub‑2 µm workflows
Compatible with elevated system pressures
Maintains performance under demanding conditions
Faster Equilibration
Reduced run‑to‑run cycle times
Increased analytical throughput
Typical Applications
UHPLC and LC‑MS analytical workflows
Steroidal compound analysis
Structural isomer separations
Lipids and hydrophobic analytes
Peptides, proteins, and oligonucleotides
Methods requiring shape‑selectivity preservation