Guard Column Starter Set, UDC Cholesterol 2.o, complete with 5 each 2.0 mm ID x 10 mm long cartridges packed with 2.2 um, 120 A phase and 1 each guard column holder. Cogent TYPE-C Brand. 1 EA.
Additional Info:
The 69269‑PG1 Cogent UDC‑Cholesterol 2.0 Guard Column Starter Set is a complete high‑pressure protection system designed for UHPLC and LC‑MS workflows, where maintaining column efficiency and shape‑selective performance is critical.
This starter kit includes:
(1) Stainless steel guard column holder designed for high‑pressure operation
(5) UDC‑Cholesterol 2.0 guard cartridges
2.0 mm ID × 10 mm length
Packed with 2.2 µm, 120 Å TYPE‑C™ silica hydride UDC‑Cholesterol 2.0 phase
Each cartridge is individually packaged in a protective Delrin™ case, preventing contamination, drying, or damage before use.
Designed for 2.1 mm UHPLC Columns
This guard column system is optimized for:
2.1 mm ID UHPLC and analytical columns
Sub‑2 µm particle methods
LC‑MS workflows requiring high sensitivity
Proper guard column integration ensures:
Minimal band broadening
Maintained high efficiency and resolution
Consistent retention and selectivity
Why Use a UHPLC Guard Column System
UHPLC columns using 2.2 µm particles are highly sensitive to:
Particulates and contamination
Strongly retained analytes
Sample matrix buildup
Pressure increases due to blockages
The 69269‑PG1 starter kit provides a critical sacrificial protection layer, helping to:
Preserve column efficiency and resolution
Prevent rapid pressure buildup
Extend UHPLC column lifetime
Maintain reproducibility in high‑performance methods
In typical use, the five included cartridges often protect an analytical column for its usable lifetime, depending on sample cleanliness.
UDC‑Cholesterol™ 2.0 Guard Phase Advantages
Using a matched guard phase ensures:
Identical shape selectivity and retention behavior
No method disruption
Seamless analyte transfer to the analytical column
Shape‑Selective Interaction
Separates compounds based on 3D structure and steric fit
Ideal for isomers and structurally similar analytes
Strong Hydrophobic Interaction
Effective retention of lipids and hydrophobic compounds
Tunable Selectivity
Optimize separations using:
Temperature adjustments
Mobile phase composition
Cogent TYPE‑C™ Technology Benefits
Silica Hydride Surface
Direct Si–C bonding (no end‑capping required)
Reduced silanol interactions
Improved peak shape for basic and polar analytes
High‑Pressure Stability
Designed for UHPLC / sub‑2 µm workflows
Compatible with elevated system pressures
Maintains performance under demanding conditions
Faster Equilibration
Reduced cycle times
Increased throughput for high‑efficiency methods
Typical Applications
UHPLC and LC‑MS analytical workflows
Steroidal compound analysis
Structural isomer separations
Lipids and hydrophobic analytes
Peptides, proteins, and oligonucleotides
Methods requiring shape‑selectivity preservation