Catalog Number - 58846-02-002

58846-02-002 ARE‑Applied Research Mobile Phase Inlet Filters are high‑performance, biocompatible solvent filtration devices designed for HPLC, UHPLC, and LC‑MS mobile phase delivery systems, balancing maximum solvent utilization, high throughput, and system protection.

These filters incorporate a “Last Drop” flat‑profile design, allowing nearly complete use of mobile phase solvents in reservoir bottles—especially valuable for long analytical runs, overnight sequences, and expensive solvent systems.

Each filter is constructed with a 2.5 µm PTFE filter element and an inert PEEK / PTFE wetted flow path, ensuring low extractables, broad chemical compatibility, and consistent performance across demanding analytical workflows.

✅ Explore additional pack sizes and purchasing options to support lab efficiency and inventory control

“Last Drop” Design – Maximum Solvent Utilization

• Wide 22 mm flat filter geometry

• Positions at the lowest point in the bottle

• Draws solvent to near‑empty conditions

• Reduces waste and minimizes interruptions

✅ Ideal for long runs, high‑throughput labs, and solvent‑intensive methods

✅ Helps improve workflow efficiency and cost control

2.5 µm PTFE Element – Biocompatible System Protection

• Filters particulates ≥ 2.5 µm

• Protects:

  • Pump seals and check valves

  • Injection systems

  • Columns and detectors

• PTFE media provides:

  • Broad chemical compatibility

  • Biocompatibility for sensitive applications

  • Low adsorption and extractables

✅ Ideal for pharmaceutical, bioanalytical, and LC‑MS applications

Visual Inspection Advantage – White Filter Media

• White PTFE element allows easy visualization of trapped particles

• Enables fast assessment of filter loading

• Simplifies maintenance and replacement decisions

✅ Supports proactive maintenance and system uptime

PEEK / PTFE Flow Path – High Purity Performance

• All wetted materials composed of:

  • PEEK (polyether ether ketone)

  • PTFE (inert fluoropolymer)

• Provides:

  • Chemical inertness

  • Low leachables

  • Stable solvent compatibility

✅ Suitable for high‑purity and LC‑MS workflows

1/16" Connector with ETFE Ferrule – Secure Tubing Integration

• Integrated 1/16" tubing connector

• Includes ETFE ferrule for secure retention

• Designed for non‑flanged low‑pressure tubing

• Leak‑free performance without complex fittings

✅ Enables fast, reliable installation in solvent delivery systems

Performance Advantages – Modern Chromatography Systems

Compared to conventional inlet filters:

• Maximizes usable solvent volume

• Reduces risk of air entering pump systems

• Improves flow stability at low solvent levels

• Supports continuous, unattended runs

Modern best practices emphasize:

• High surface area filtration

• Low restriction for stable flow

• Effective particulate removal for system protection

✅ These filters meet current HPLC system performance expectations

System Compatibility & Use

Designed for use with:

• HPLC / UHPLC mobile phase systems

• LC‑MS solvent delivery setups

• Low‑pressure tubing configurations

• Standard solvent reservoir bottles

✅ Installs directly into mobile phase bottles for inline filtration

Typical Applications

• HPLC mobile phase filtration

• LC‑MS solvent protection

• Biocompatible analytical workflows

• High‑throughput laboratories

• Long‑duration and unattended runs

• Integrated into original equipment manufacturer (OEM) product designs

Important Usage Notes

• Designed for low‑pressure systems only

• Ensure tubing is properly seated with ferrule

• Inspect filter regularly for particle buildup

• Replace element when flow restriction increases