Catalog Number - 69069-PG5

The 69069‑PG5 Cogent UDC‑Cholesterol Guard Column Cartridges are replacement cartridges designed to protect standard‑flow analytical HPLC columns while preserving the unique shape‑selective performance of the UDC‑Cholesterol stationary phase.

Each cartridge is:

• 4.0 mm ID × 10 mm length

• Packed with 4 µm, 100 Å TYPE‑C™ silica hydride UDC‑Cholesterol phase

• Constructed in stainless steel housings with SS frits

Cartridges are individually packaged in protective Delrin™ cases, preventing contamination, drying, and damage prior to use.

⚠️ Requires guard column holder (sold separately)

Designed for Standard Analytical Column IDs

These guard cartridges are optimized for:

• 3.0 mm ID solvent‑saving columns

• 4.0 mm ID analytical columns

• 4.6 mm ID standard HPLC columns

Ideal for conventional HPLC systems, ensuring:

• Minimal impact on peak shape

• Maintained chromatographic efficiency

• Consistent retention and reproducibility

Why Use Replacement Guard Cartridges

Analytical columns are exposed to:

• Particulates and contaminants

• Strongly retained compounds

• Sample matrix buildup

• Irreversible adsorption

The 69069‑PG5 cartridges act as a sacrificial protection layer, helping to:

• Extend analytical column lifetime significantly

• Maintain chromatographic performance

• Reduce downtime and replacement costs

• Improve reproducibility across runs

Cartridges can be replaced quickly without disturbing the analytical column.

UDC‑Cholesterol™ Guard Phase Advantages

Using the same stationary phase as your analytical column ensures:

• Matched shape selectivity and retention behavior

• No change to method performance

• Seamless analyte transfer

Shape‑Selective Interaction

• Separates compounds based on 3D molecular structure and steric fit

• Ideal for isomers and structurally similar analytes

Strong Hydrophobic Retention

• Effective for lipids and hydrophobic analytes

• Enhances retention of difficult compounds

Tunable Selectivity

• Modify separations using:

  • Temperature changes

  • Mobile phase composition

Cogent TYPE‑C™ Technology Benefits

Silica Hydride Surface

• Direct Si–C bonding (no end‑capping required)

• Reduced silanol interactions

• Improved peak shape for basic and polar analytes

Faster Equilibration

• Reduced cycle times

• Increased analytical throughput

Durability

• Resistant to hydrolysis

• Long cartridge and column lifetime

• Stable under demanding analytical conditions

Typical Applications

• Standard analytical HPLC workflows

• Steroidal compound analysis

• Structural isomer separations

• Lipids and hydrophobic analytes

• Peptides, proteins, and oligonucleotides

• Methods requiring shape‑selectivity protection